国际脑血管病杂志
國際腦血管病雜誌
국제뇌혈관병잡지
INTERNATIONAL JOURNAL OF CEREBROVASCULAR DISEASES
2013年
9期
711-716
,共6页
脑缺血%鸟苷酸激酶%膜蛋白质类%受体,N-甲基-D-天冬氨酸%突触后密集区
腦缺血%鳥苷痠激酶%膜蛋白質類%受體,N-甲基-D-天鼕氨痠%突觸後密集區
뇌결혈%조감산격매%막단백질류%수체,N-갑기-D-천동안산%돌촉후밀집구
Brain Ischemia%Guanylate Kinase%Membrane Proteins%Receptors,N-Methyl-D-Aspartate%Post-Synaptic Density
膜相关性鸟苷酸激酶(membrane associated guanylate kinase,MAGUK)是一类突触后致密蛋白(postsynaptic density,PSD),定位于突触后膜的突触后致密区,包括PSD-95、SAP-102、PSD-93和SAP-97.MAGUK家族成员含有多个蛋白结合位点,这些特殊的结合位点负责介导多种信号的转导.MAGUK参与中枢神经系统疾病发生和发展机制,已成为神经科学研究的热点.文章简要综述了MAGUK在缺血性脑损伤中的作用.
膜相關性鳥苷痠激酶(membrane associated guanylate kinase,MAGUK)是一類突觸後緻密蛋白(postsynaptic density,PSD),定位于突觸後膜的突觸後緻密區,包括PSD-95、SAP-102、PSD-93和SAP-97.MAGUK傢族成員含有多箇蛋白結閤位點,這些特殊的結閤位點負責介導多種信號的轉導.MAGUK參與中樞神經繫統疾病髮生和髮展機製,已成為神經科學研究的熱點.文章簡要綜述瞭MAGUK在缺血性腦損傷中的作用.
막상관성조감산격매(membrane associated guanylate kinase,MAGUK)시일류돌촉후치밀단백(postsynaptic density,PSD),정위우돌촉후막적돌촉후치밀구,포괄PSD-95、SAP-102、PSD-93화SAP-97.MAGUK가족성원함유다개단백결합위점,저사특수적결합위점부책개도다충신호적전도.MAGUK삼여중추신경계통질병발생화발전궤제,이성위신경과학연구적열점.문장간요종술료MAGUK재결혈성뇌손상중적작용.
Membrane-associated guanylate kinases (MAGUKs) is a class of postsynaptic density proteins (PSDs) in the postsynaptic dense of the postsynaptic membrane,including PSD-95,SAP-102,PSD-93,and SAP-97.MAGUK family members contain several protein binding sites,and these special binding sites are responsible for mediating a variety of signal transduction.MAGUKs participate in the occurrence and development mechanisms in central nervous system diseases,and has become a topic of general interest of neuroscience.This article briefly reviews the roles of MAGUKs in ischemic brain injury.
