国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2012年
6期
366-369
,共4页
银屑病%生物制剂%免疫
銀屑病%生物製劑%免疫
은설병%생물제제%면역
Psoriasis%Biologics%Immunity
近10年来,随着对银屑病免疫学机制和易感基因研究的不断深入,越来越多针对关键发病环节的靶向性生物制剂被研发出来用于控制这一顽疾.根据作用机制的不同,银屑病生物制剂主要分为阻断共刺激信号和抑制炎症介质两种.其中,肿瘤坏死因子α、白介素12及白介素23为其主要的炎症介质靶点.对目前欧美已经批准上市和尚未批准,但较有潜力的多种银屑病生物制剂的作用机制、临床疗效及安全性进行阐述.
近10年來,隨著對銀屑病免疫學機製和易感基因研究的不斷深入,越來越多針對關鍵髮病環節的靶嚮性生物製劑被研髮齣來用于控製這一頑疾.根據作用機製的不同,銀屑病生物製劑主要分為阻斷共刺激信號和抑製炎癥介質兩種.其中,腫瘤壞死因子α、白介素12及白介素23為其主要的炎癥介質靶點.對目前歐美已經批準上市和尚未批準,但較有潛力的多種銀屑病生物製劑的作用機製、臨床療效及安全性進行闡述.
근10년래,수착대은설병면역학궤제화역감기인연구적불단심입,월래월다침대관건발병배절적파향성생물제제피연발출래용우공제저일완질.근거작용궤제적불동,은설병생물제제주요분위조단공자격신호화억제염증개질량충.기중,종류배사인자α、백개소12급백개소23위기주요적염증개질파점.대목전구미이경비준상시화상미비준,단교유잠력적다충은설병생물제제적작용궤제、림상료효급안전성진행천술.
With the progress in the understanding of immunological mechanisms and susceptibility genes of psoriasis,an increasing number of targeted biological agents have been developed over the past decade.According to the mechanism of action,these agents are mainly divided into two groups,including costimulatory signal-blocking agents and inflammatory mediator-inhibiting agents.Inflammatory mediators targeted by these agents mainly include tumor necrosis factor α,interleukin-12 and interleukin-23.This review introduces the mechanism,clinical efficacy and safety of many biological agents which have been approved or unapproved but have shown vast potential for treating psoriasis in Europe and America.
