CAJ | 학술논문

Th17/IL-17免疫途径是自身免疫性疾病发生的重要机制,这条途径也参与了许多免疫性皮肤病的发生.免疫抑制剂及免疫调节剂已广泛用于自身免疫性炎症性皮肤病的治疗,其作用机制复杂.近年来研究表明,抑制Th17/IL-17轴是免疫调节性药物作用于机体的一种新途径.皮肤科常用药物环孢素、雷公藤、维A酸、维生素D、他克莫司及麦考酚酸对Th17/IL-17途径有抑制作用,探讨这些药物新的免疫调节机制,为临床更好地应用提供理论依据,以便将其更广泛地用于Th17细胞介导的疾病,同时,为寻找针对这条路径的药物作用靶点提供思路.
Th17/IL-17면역도경시자신면역성질병발생적중요궤제,저조도경야삼여료허다면역성피부병적발생.면역억제제급면역조절제이엄범용우자신면역성염증성피부병적치료,기작용궤제복잡.근년래연구표명,억제Th17/IL-17축시면역조절성약물작용우궤체적일충신도경.피부과상용약물배포소、뢰공등、유A산、유생소D、타극막사급맥고분산대Th17/IL-17도경유억제작용,탐토저사약물신적면역조절궤제,위림상경호지응용제공이론의거,이편장기경엄범지용우Th17세포개도적질병,동시,위심조침대저조로경적약물작용파점제공사로.
The T-helper typer 17 cells/interleukin 17 (Th17/IL-17) axis,which plays an important role in the pathogenesis of autoimmune diseases,is also implicated in the development of many immune-mediatedskin diseases.Immunosuppressants and immunoregulators have been extensively used in the treatment of autoimmune and inflammatory skin diseases.The exact action mechanisms of these drugs are complicated,andrecent studies have demonstrated that they may exert immunoregulatory roles by inhibiting the Th17/IL-17 axis.Many drugs commonly used in dermatology,such as cyclosporine A,triptolide,tretinoin,vitamin D,tacrolimusand mycophenolic acid,have shown an inhibitory effect on the Th17/IL-17 pathway.To explore new action mechanisms of these immunoregulatory drugs may provide theoretical basis for their wider application in the treatment of Th17-mediated autoimmune diseases,and offer clues to further researches for therapeutic targetsin the Th17/IL-17 axis.