CAJ | 학술논문

干燥综合征是一种慢性自身免疫性炎症性疾病,以外分泌腺中显著的淋巴细胞浸润和血清中存在多种自身抗体为主要特点.当不伴有其他自身免疫性疾病时,称为原发性干燥综合征.原发性干燥综合征的发病机制尚不明确,目前认为,该病在易感基因的基础上,由多种环境因素和内在抗原参与,导致机体的细胞免疫和体液免疫发生异常的反应,从而破坏外分泌腺,并产生自身抗体造成靶器官的损害.该病虽然缺乏理想的治疗方法,但近些年来生物制剂的研究应用带来新的启示.
간조종합정시일충만성자신면역성염증성질병,이외분비선중현저적림파세포침윤화혈청중존재다충자신항체위주요특점.당불반유기타자신면역성질병시,칭위원발성간조종합정.원발성간조종합정적발병궤제상불명학,목전인위,해병재역감기인적기출상,유다충배경인소화내재항원삼여,도치궤체적세포면역화체액면역발생이상적반응,종이파배외분비선,병산생자신항체조성파기관적손해.해병수연결핍이상적치료방법,단근사년래생물제제적연구응용대래신적계시.
Sj(o)gren's syndrome(SS)is a chronic autoimmune inflammatory disease characterized by predominant infiltration of lymphocytes in exocrine glands as well as presence of several autoantibodies in sera.Primary SS(pSS)is the condition in the absence of other definitively diagnosed autoimmune diseases.The pathogenesis of pSS remains unclear.Currently,pSS is considered to be induced by multiple environmental factors and endogenous antigens,which trigger a self-perpetuating inflammatory response in susceptible individuals,lead to abnormal cellular and humoral immunity followed by the impairment of exocrine glands,production of autoantibodies and damage to target organs.Although no ideal therapy is available,biological agents have offered new clues to the treatment of pSS.