CAJ | 학술논문

微针是具有不同的材料和形状的针状结构,作用于皮肤形成微米尺寸的小孔,利于药物穿透角质层吸收的一种新型经皮给药系统,伴随着微电子工业和材料学的发展而发展.传统的基于微针的经皮胶原蛋白诱导疗法,在痤疮、皮肤色素沉着、瘢痕、皱纹以及改善肤色等美容治疗方面发挥了作用.近年来,微针辅助治疗皮肤肿瘤也有新的研究进展.由于其独特的经皮给药模式、高安全性和便携性,对于某些顽固难治的浅表性皮肤疾病,微针结合外用药物具有广阔的临床应用前景.
미침시구유불동적재료화형상적침상결구,작용우피부형성미미척촌적소공,리우약물천투각질층흡수적일충신형경피급약계통,반수착미전자공업화재료학적발전이발전.전통적기우미침적경피효원단백유도요법,재좌창、피부색소침착、반흔、추문이급개선부색등미용치료방면발휘료작용.근년래,미침보조치료피부종류야유신적연구진전.유우기독특적경피급약모식、고안전성화편휴성,대우모사완고난치적천표성피부질병,미침결합외용약물구유엄활적림상응용전경.
Microneedles are a new transdermal drug delivery system(TDDS)derived from microelectro-mechanical systems.The needle-like structures in different materials and shapes,which have improved with the development of microelectronics industry and material science,can remarkably increase the permeability of drugs by forming minimal pores in stratum corneum.The traditional microneedle-based percutaneous collagen induction therapy is currently used to treat acne,as well as to improve cutaneous pigmentation,scars,wrinkles and skin tone.Recently,some advances have been achieved in the treatment of superficial skin tumors with microneedles.Due to their unique transdermal delivery mode,high security and portability,microneedles combined with topical medications will have a wide range of clinical applications in the treatment of some intractable superficial skin diseases.