CAJ | 학술논문

肥大细胞释放组胺在变态反应和非变态反应发病机制中均起重要作用.研究表明,肥大细胞主要通过免疫学途径和非免疫学途径释放组胺,多种物质参与组胺释放过程.特异性IgE介导肥大细胞释放组胺是肥大细胞激活的典型方式.抗FcεRI抗体和抗IgE抗体在慢性特发性荨麻疹肥大细胞释放组胺机制中起作用.凝血机制中生成的凝血酶可激活蛋白酶激活受体,介导肥大细胞黏附于纤维连接蛋白,诱发肥大细胞释放组胺.遗传因素、神经精神因素及物理因素也参与荨麻疹患者肥大细胞释放组胺.
비대세포석방조알재변태반응화비변태반응발병궤제중균기중요작용.연구표명,비대세포주요통과면역학도경화비면역학도경석방조알,다충물질삼여조알석방과정.특이성IgE개도비대세포석방조알시비대세포격활적전형방식.항FcεRI항체화항IgE항체재만성특발성담마진비대세포석방조알궤제중기작용.응혈궤제중생성적응혈매가격활단백매격활수체,개도비대세포점부우섬유련접단백,유발비대세포석방조알.유전인소、신경정신인소급물리인소야삼여담마진환자비대세포석방조알.
Histamine is the most important inflammatory mediator in urticaria.Histamine release from mast cells plays a key role in the pathogenesis of allergic disorders and non-allergic reactions.Researches have shown that mast cells release histamine via both immunological and non-immunological pathways.Many substances participate in the process of histamine release.The typical way to activate mast cells is through specific IgEs.Both anti-high affinity IgE receptor(FcεRI)antibodies and anti-IgE antibodies are involved in histamine release by mast cells in chronic idiopathic urticaria.Thrombin generated during blood coagulation can activate proteinase-activated receptors,which mediate mast cell adhesion to fibronectin,and induce histamine release from mast cells.Genetic factors,neurological and psychiatric factors,as well as physical factors are also involved in histamine release by mast cells in urticaria.