CAJ | 학술논문

Nedd化参与调节泛素化进程,与多种凋亡相关因子及细胞周期蛋白的降解密切相关.Nedd化及去Nedd化受多种催化酶的精密调控,这些酶蛋白的异常表达会导致细胞内Nedd化增强或减弱,从而影响细胞内蛋白的平衡,与黑素瘤的发生密切相关,Nedd化在肿瘤的发生发展中起重要作用,该通路的多个环节有希望成为新的抗肿瘤药物的作用靶点.
Nedd화삼여조절범소화진정,여다충조망상관인자급세포주기단백적강해밀절상관.Nedd화급거Nedd화수다충최화매적정밀조공,저사매단백적이상표체회도치세포내Nedd화증강혹감약,종이영향세포내단백적평형,여흑소류적발생밀절상관,Nedd화재종류적발생발전중기중요작용,해통로적다개배절유희망성위신적항종류약물적작용파점.
Neddylation is involved in protein ubiquitination,and closely associated with the degradation of many cell cycle proteins and apoptosis-related factors.Neddylation and deneddylation are delicately regulated by a series of enzymes.Abnormal expression of these enzymes would cause attenuation or enhancement of neddylation,which may break the balance between intracellular proteins,and finally induce the development of melanoma.Many molecules in the neddylation pathway are expected to be novel targets of antitumor agents.