国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2013年
6期
371-373
,共3页
董洪军%白倩倩%汪晨%姚志远
董洪軍%白倩倩%汪晨%姚誌遠
동홍군%백천천%왕신%요지원
肥大细胞%光%创伤和损伤
肥大細胞%光%創傷和損傷
비대세포%광%창상화손상
Mast cells%Light%Wounds and injuries
慢性光损伤是最常见的皮肤损害,由于长期接受紫外线照射所导致.研究表明,长期曝光部位皮肤中肥大细胞的数量较非曝光部位明显增多;肥大细胞在紫外线诱导的皮肤免疫抑制中发挥一定的作用.在慢性光损伤过程中,肥大细胞通过分泌基质金属蛋白酶和类胰蛋白酶等,参与光损伤中细胞外基质及基底膜的破坏;又通过分泌细胞因子如IL-10等,限制了小鼠皮肤慢性光损伤的病理过程.
慢性光損傷是最常見的皮膚損害,由于長期接受紫外線照射所導緻.研究錶明,長期曝光部位皮膚中肥大細胞的數量較非曝光部位明顯增多;肥大細胞在紫外線誘導的皮膚免疫抑製中髮揮一定的作用.在慢性光損傷過程中,肥大細胞通過分泌基質金屬蛋白酶和類胰蛋白酶等,參與光損傷中細胞外基質及基底膜的破壞;又通過分泌細胞因子如IL-10等,限製瞭小鼠皮膚慢性光損傷的病理過程.
만성광손상시최상견적피부손해,유우장기접수자외선조사소도치.연구표명,장기폭광부위피부중비대세포적수량교비폭광부위명현증다;비대세포재자외선유도적피부면역억제중발휘일정적작용.재만성광손상과정중,비대세포통과분비기질금속단백매화류이단백매등,삼여광손상중세포외기질급기저막적파배;우통과분비세포인자여IL-10등,한제료소서피부만성광손상적병리과정.
Chronic photoaging is the most common form of skin damage caused by long-term ultraviolet (UV) irradiation.Studies have shown that the number of mast cells is significantly higher in sun-exposed skin than in non-sun-exposed skin,and mast cells play a certain role in UV-induced cutaneous immunosuppression.In the process of photoaging,mast cells may induce the destruction of extracellular matrix and basement membrane by secreting matrix metalloproteinases and tryptase,and slow down the pathological process of photoaging of mouse skin by secreting cytokines such as interleukin-10.