国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2013年
6期
380-383
,共4页
皮肤疾病%泛素类%去泛素化酶
皮膚疾病%汎素類%去汎素化酶
피부질병%범소류%거범소화매
Skin diseases%Ubiquitins%Deubiquitinating enzymes
去泛素化酶家族种类繁多,分布于人体多种器官及组织,是泛素-蛋白酶体途径的重要组成部分,精细调控真核细胞生物细胞内蛋白的降解.A20、CYLD、泛素特异性加工酶7等去泛素化酶通过与外异蛋白受体、Fas相关的死亡区蛋白、B细胞淋巴因子-3、核因子-κB抑制蛋白激酶等因子相互作用,可参与银屑病、皮肤基底细胞癌、皮肤鳞状细胞癌、皮肤附属器肿瘤、Kaposi肉瘤以及恶性黑素瘤等皮肤疾病的发生发展.探讨去泛素化酶作用机制,有助于为炎症及肿瘤性皮肤病提供新的治疗靶点.
去汎素化酶傢族種類繁多,分佈于人體多種器官及組織,是汎素-蛋白酶體途徑的重要組成部分,精細調控真覈細胞生物細胞內蛋白的降解.A20、CYLD、汎素特異性加工酶7等去汎素化酶通過與外異蛋白受體、Fas相關的死亡區蛋白、B細胞淋巴因子-3、覈因子-κB抑製蛋白激酶等因子相互作用,可參與銀屑病、皮膚基底細胞癌、皮膚鱗狀細胞癌、皮膚附屬器腫瘤、Kaposi肉瘤以及噁性黑素瘤等皮膚疾病的髮生髮展.探討去汎素化酶作用機製,有助于為炎癥及腫瘤性皮膚病提供新的治療靶點.
거범소화매가족충류번다,분포우인체다충기관급조직,시범소-단백매체도경적중요조성부분,정세조공진핵세포생물세포내단백적강해.A20、CYLD、범소특이성가공매7등거범소화매통과여외이단백수체、Fas상관적사망구단백、B세포림파인자-3、핵인자-κB억제단백격매등인자상호작용,가삼여은설병、피부기저세포암、피부린상세포암、피부부속기종류、Kaposi육류이급악성흑소류등피부질병적발생발전.탐토거범소화매작용궤제,유조우위염증급종류성피부병제공신적치료파점.
There are a great variety of deubiquitinating enzymes (DUBs) distributed in multiple human tissues and organs.As an important part of ubiquitin-proteasome pathway (UPP),DUBs can tightly control the degradation of eukaryotic intracellular proteins.It has been revealed that some deubiquitinating enzymes such as A20,cylindromatosis (CYLD) and ubiquitin-specific processing protease-7 (USP7) may take part in the occurrence and development of psoriasis,basal cell carcinoma,squamous cell carcinoma,cutaneous adnexal neoplasms,Kaposi's sarcoma and malignant melanoma through interaction with ectodysplasin-A receptor (EDAR),Fas-associated death domain-containing protein (FADD),B-cell leukemia/lymphoma 3 (Bcl-3),I kappa B kinase (IKK),and so on.Therefore,exploring the action mechanism of deubiquitinating enzymes will help to find new targets for the treatment of inflammatory dermatoses and skin tumors.
