CAJ | 학술논문

钠氢交换子调节因子-1是一种支架蛋白,其在调节离子转运、运输中发挥着一定的作用,同时还与膜-细胞骨架连接蛋白相互作用,可以稳定跨膜蛋白、参与构成上皮顶端微绒毛结构.它还是一种调节蛋白,能与30余种蛋白质作用并调节其功能.其基因的突变或杂合性丢失可导致肿瘤细胞的恶性程度增高,在正常细胞中通常为胞膜表达,发挥抑癌作用;胞膜不表达或在胞质及胞核中过表达则提示肿瘤恶性程度增加.在进一步的研究中除了不断探索其抗肿瘤的机制外,对肿瘤生物学行为的影响及临床意义将成为研究重点.
납경교환자조절인자-1시일충지가단백,기재조절리자전운、운수중발휘착일정적작용,동시환여막-세포골가련접단백상호작용,가이은정과막단백、삼여구성상피정단미융모결구.타환시일충조절단백,능여30여충단백질작용병조절기공능.기기인적돌변혹잡합성주실가도치종류세포적악성정도증고,재정상세포중통상위포막표체,발휘억암작용;포막불표체혹재포질급포핵중과표체칙제시종류악성정도증가.재진일보적연구중제료불단탐색기항종류적궤제외,대종류생물학행위적영향급림상의의장성위연구중점.
Na+/H+ exchanger regulatory factor-1 (NHERF1),a scaffolding protein,plays a certain role in the regulation of ion transport,stabilization of transmembrane proteins and construction of epithelial topmicrovilli structure via binding with membrane cytoskeleton proteins.It is also a regulatory protein that can interact with more than 30 kinds of proteins and modulate their function.Mutations or loss of heterozygosity of the NHERF1 gene can lead to an increase in the degree of malignancy of tumor cells.In normal cells,NHERF1 is usually expressed in cytomembrane and acts as a tumor suppressor,and its absence in cytomembrane or overexpression in cytoplasm or nuclei is often associated with an increase in the degree of malignancy.In addition to anti-tumor mechanism,influences on tumor biological behavior as well as clinical implications of NHERF1 will all become research foci for future.