CAJ | 학술논문

疱疹样皮炎是一种与肠病有关的谷胶敏感性皮肤病,皮损表现为瘙痒性的红斑、丘疹、水疱,直接免疫荧光所见的IgA在真皮乳头层颗粒状沉积对疱疹样皮炎诊断有重要价值.尽管病理学检查和直接免疫荧光一直被认为是疱疹样皮炎诊断的金标准,但对于一些症状不典型或取材位置不当无法确诊的病例,血清学检查有着不可替代的作用,血清学检查对于疱疹样皮炎患者的疗效评估和随访均具有重要价值.随着对疱疹样皮炎发病机制的不断认识,新的血清学检测技术也在不断进步,同时通过血清学检查对DH患者血清中多种抗体水平的分析,为疱疹样皮炎发病机制的研究提供了更多线索.
포진양피염시일충여장병유관적곡효민감성피부병,피손표현위소양성적홍반、구진、수포,직접면역형광소견적IgA재진피유두층과립상침적대포진양피염진단유중요개치.진관병이학검사화직접면역형광일직피인위시포진양피염진단적금표준,단대우일사증상불전형혹취재위치불당무법학진적병례,혈청학검사유착불가체대적작용,혈청학검사대우포진양피염환자적료효평고화수방균구유중요개치.수착대포진양피염발병궤제적불단인식,신적혈청학검측기술야재불단진보,동시통과혈청학검사대DH환자혈청중다충항체수평적분석,위포진양피염발병궤제적연구제공료경다선색.
Dermatitis herpetiformis (DH) is a gluten-sensitive skin disease assosiated with celiac disease (CD).Skin lesions of the disease are characterized by pruritic erythema,papules and vesicles.The presence of granular IgA deposits in dermal papillae visualized by direct immunofluorescence (DIF) is of great value to the diagnosis of DH.Although histological examination and DIF have been considered as the gold standard for the diagnosis of DH,serological tests play an irreplaceable role especially in patients whose diagnosis has not been confirmed due to atypical symptoms or improperly prepared specimens.Additionally,serological tests are very useful for the evaluation and monitoring of efficacy in patients with DH.There has been a steady progress in serological techniques along with further understanding into the pathogenesis of DH.Moreover,many clues to the pathogenesis of DH can be found through serological tests for various antibodies in patients with DH.