CAJ | 학술논문

斑秃是一种非瘢痕性的炎症性脱发性疾病,病情多能自限,但容易复发.斑秃发病机制不明,组织病理上表现为生长期毛囊周围炎症浸润及毛囊退行性变两个部分.目前研究认为,内外源因素作用于遗传易感人群引起生长期毛囊深层周围炎症细胞浸润,浸润的炎症细胞及细胞因子、神经肽等形成恶性循环,循环结局为毛囊上皮细胞凋亡,大批毛囊同时快速进入退行期,导致斑秃发生.
반독시일충비반흔성적염증성탈발성질병,병정다능자한,단용역복발.반독발병궤제불명,조직병리상표현위생장기모낭주위염증침윤급모낭퇴행성변량개부분.목전연구인위,내외원인소작용우유전역감인군인기생장기모낭심층주위염증세포침윤,침윤적염증세포급세포인자、신경태등형성악성순배,순배결국위모낭상피세포조망,대비모낭동시쾌속진입퇴행기,도치반독발생.
Alopecia areata (AA) is a kind of inflammation-induced,self-limited and non-scarring hair loss.No satisfactory treatment is available for AA at present,and relapse is frequent.The pathogenesis of AA remains unclear.Pathologically,it is characterized by inflammatory infiltrate around anagen hair follicles and degeneration of hair follicles.Most current studies suggest that inflammatory cells attack anagen hair follicles,which together with cytokines and neuropeptides constitute a vacious cycle,leading to the apoptosis in hair follicle epithelial cells followed by sudden simultaneous regression of numerous hair follicles,and,finally,causing the initiation of AA.