CAJ | 학술논문

黑素瘤起源于表皮黑素细胞,是死亡率最高的恶性肿瘤.目前,倾向将黑素瘤分为四种亚型:肢端型、黏膜型、慢性日光损伤型和非慢性日光损伤型.病因学研究中环境因素和遗传易感性是黑素瘤主要致病因素.kit基因是定位于人类染色体4q11-12的原癌基因,研究发现,其是亚洲黑素瘤重要的致病基因.kit基因在肢端型和黏膜型黑素瘤中突变率较高,对黑素瘤肿瘤生长及预后判断具有重要意义.针对kit基因的分子靶向治疗是目前研究的热点.
흑소류기원우표피흑소세포,시사망솔최고적악성종류.목전,경향장흑소류분위사충아형:지단형、점막형、만성일광손상형화비만성일광손상형.병인학연구중배경인소화유전역감성시흑소류주요치병인소.kit기인시정위우인류염색체4q11-12적원암기인,연구발현,기시아주흑소류중요적치병기인.kit기인재지단형화점막형흑소류중돌변솔교고,대흑소류종류생장급예후판단구유중요의의.침대kit기인적분자파향치료시목전연구적열점.
Melanoma,a malignant tumor originated from epidermal melanocytes,presents the highest mortality rate of all types of skin cancers.At present,melanoma is classified into four subtypes:acral melanoma,mucosal melanoma,skin melanoma with chronic sun-induced damage,and skin melanoma without chronic sun-induced damage.Environmental factors and genetic susceptibility are considered to be the key pathogenic mechanisms in melanoma.Kit gene,an oncogene located on chromosome 4q1 1-12,is considered to be an important pathogenic factor for melanoma in Asian.The mutations of kit gene,which are of great value for the growth and prognosis prediction of melanoma,are more common in acral and mucosal melanoma than in other types of melanoma.The kit gene-targeted therapy has become a hot spot in recent studies.