CAJ | 학술논문

受体活性修饰蛋白(RAMPs)是一种具有单一跨膜功能域的蛋白,它可以与降钙素基因相关肽家族(CGRP)受体、降钙素受体(CTR)及降钙素受体样受体(CRLR)等Ⅱ型G蛋白偶联受体(GPCRs)相互作用,形成稳定的异二聚体在细胞膜上表达.不同的RAMPs可与降钙素受体样受体(CRLR)或降钙素受体(CTR)结合,形成对配体具有特异性亲和的不同受体表型,从而决定受体的生物学效应.此外,RAMPs还能与其他GPCRs相互作用,表明RAMPs在G蛋白偶联受体功能调节中具有更为广泛的作用.RAMPs对GPCRs的调节依赖于它的分子基础.RAMPs的研究为GPCRs受体功能及CGRP信号转导的研究提供了新思路.
수체활성수식단백(RAMPs)시일충구유단일과막공능역적단백,타가이여강개소기인상관태가족(CGRP)수체、강개소수체(CTR)급강개소수체양수체(CRLR)등Ⅱ형G단백우련수체(GPCRs)상호작용,형성은정적이이취체재세포막상표체.불동적RAMPs가여강개소수체양수체(CRLR)혹강개소수체(CTR)결합,형성대배체구유특이성친화적불동수체표형,종이결정수체적생물학효응.차외,RAMPs환능여기타GPCRs상호작용,표명RAMPs재G단백우련수체공능조절중구유경위엄범적작용.RAMPs대GPCRs적조절의뢰우타적분자기출.RAMPs적연구위GPCRs수체공능급CGRP신호전도적연구제공료신사로.
Receptor activity modifying proteins (RAMPs) is a kind protein with transmembrane functionality.RAMPs can interact with TypeⅡ G protein coupled receptors (GPCRs) such as calcitonin gene-related peptide receptor (CGRPR),calcitonin receptor (CTR) and calcitonin receptor-like receptor (CRLR),to form a stable heterodimer expression on the cell membrane.Different RAMPs can combine with CRLR or CTR to produce different receptor phenotypes with ligand-specific affinity and thus can decide biological effect of the receptors.In addition,RAMPs can also interact with other GPCRs,which promise broader application in function regulation of G-proteincoupled receptor of RAMPs'.RAMPs' regulation of GPCRs depends on its molecular basis.Our studies of RAMPs provides a new perspective to further researches on GPCRs functionality and CGRP signal transduction.