CAJ | 학술논문

肺是冲击波作用于人体时易于受伤的靶器官之一.肺冲击伤在战时和平时意外爆炸事故中较多见,是军事医学和灾害医学中的重要研究课题之一.肺受冲击波致伤后会引起机体生理、病理、生化方面的改变,引发肺部炎性反应和细胞凋亡,并激活TNF-α、IL-6、IL-8、IL-1β等细胞炎性因子,最终导致急性呼吸窘迫综合征(ARDS).介绍了肺冲击伤的衍生过程和损伤特点,以及实验室模拟肺冲击伤的4种常用致伤装置即生物激波管、分段冲击波发生器、微型冲击波发生器、激光调控应力波发生器；此外,还列举了肺冲击伤的评分标准、病理和生化的检测指标.旨在为肺冲击伤实验动物的建模提供参考.
폐시충격파작용우인체시역우수상적파기관지일.폐충격상재전시화평시의외폭작사고중교다견,시군사의학화재해의학중적중요연구과제지일.폐수충격파치상후회인기궤체생리、병리、생화방면적개변,인발폐부염성반응화세포조망,병격활TNF-α、IL-6、IL-8、IL-1β등세포염성인자,최종도치급성호흡군박종합정(ARDS).개소료폐충격상적연생과정화손상특점,이급실험실모의폐충격상적4충상용치상장치즉생물격파관、분단충격파발생기、미형충격파발생기、격광조공응력파발생기；차외,환열거료폐충격상적평분표준、병리화생화적검측지표.지재위폐충격상실험동물적건모제공삼고.
Due to the air-filled alveoli and delicate vascular structure,the lung is the most easily damaged organ when human or animal is subjected to a shock wave.Primary pulmonary blast injury resulting from shock wave is an important cause of trauma not only in military conflicts but also in terrorism or accidents involving civilians.The physiological,pathological and biochemical changes after blast injury may lead to inflammatory response,cell apoptosis in the lung,boost the activation of cytokines including TNF-α,IL-6,IL-8 and IL-1β,and finally result in acute respiratory distress syndrome (ARDS).This paper presents the evolution and characteristics of pulmonary blast injury,and demonstrates four relevant experimental setups including biological shock tube,segmented shock wave generator,mini blast wave generator and laser-induced stress wave generator.Besides,this paper reviews the scoring system of pulmonary blast injury,pathological and biochemical measurement aiming to provide helpful reference to establish pulmonary blast injury models.