CAJ | 학술논문

软骨是缺乏血运的组织,创伤后很难利用自身的间充质干细胞进行修复,难以自愈,持续的关节软骨缺损可引发局部疼痛、水肿反应以及功能障碍、运动受限等其他症状.以往的临床治疗方法包括骨髓刺激法、软骨膜移植、自体软骨细胞移植等,但效果有限.富血小板血浆(PRP)是自体血提取的血小板浓缩物,含有丰富的生长因子及其他组织再生必须的细胞因子,可为软骨细胞生存提供良好的微环境,有望成为促进软骨再生的新方法.
연골시결핍혈운적조직,창상후흔난이용자신적간충질간세포진행수복,난이자유,지속적관절연골결손가인발국부동통、수종반응이급공능장애、운동수한등기타증상.이왕적림상치료방법포괄골수자격법、연골막이식、자체연골세포이식등,단효과유한.부혈소판혈장(PRP)시자체혈제취적혈소판농축물,함유봉부적생장인자급기타조직재생필수적세포인자,가위연골세포생존제공량호적미배경,유망성위촉진연골재생적신방법.
Cartilage is vulnerable to traumatic injury and unable to facilitate a satisfactory healing response due to its poor vascularity and inability to access mesenchymal stem cells.Continuous defects in the joint surfaces cause pain,swelling,and mechanical symptoms that result in functional impairment and limitation of athletic participation.Commonly used repair techniques include marrow stimulation,structural osteo-articular autografts or chondrocyte implantation.Platelet-rich plasma (PRP) is a concentrate extract of platelets from autologous blood,which is rich in growth factors and other cytokines and provides local environment for tissue regeneration and lends a possible option for the stimulation and acceleration of cartilage regeneration.This review gives summarization on the current state of the use of PRP for cartilage regeneration.