CAJ | 학술논문

目前,干细胞由于具有自我复制性及多向分化性,其被公认为是组织工程中最有希望的一类种子细胞.为了将其应用到组织工程中,研究者尝试了各种理化方法来促进干细胞的增殖、功能及分化,并取得了良好的效果.近年来,电刺激作为一种新兴的物理刺激手段,得到了研究者们越来越多的重视,并被证实对干细胞的增殖分化等具有良好的效果.综述了电刺激促进干细胞功能及分化方面的研究进展,并对电刺激促进干细胞分化的相关机理进行了初步探讨.
목전,간세포유우구유자아복제성급다향분화성,기피공인위시조직공정중최유희망적일류충자세포.위료장기응용도조직공정중,연구자상시료각충이화방법래촉진간세포적증식、공능급분화,병취득료량호적효과.근년래,전자격작위일충신흥적물리자격수단,득도료연구자문월래월다적중시,병피증실대간세포적증식분화등구유량호적효과.종술료전자격촉진간세포공능급분화방면적연구진전,병대전자격촉진간세포분화적상관궤리진행료초보탐토.
Nowadays,stem cells are recognized as the most promising seed cells of tissue engineering due to their self replication ability and multilineage differentiation potential.In order to apply them to tissue engineering,a variety of physical and biochemical methods were tried to promote the proliferation,function and differentiation,and good effects were achieved.Recently,as a rising method of physical stimulation,electrical stimulation received more and more attention and had been proved to have good effects on stem cell proliferation and differentiation.This paper summarized the advances in promoting effects of electrical stimulation on stem cell proliferation and differentiation,and discussed the possible mechanisms of stem cell differentiation induced by electrical stimulation.