CAJ | 학술논문

脊髓损伤是医学界急需解决的难题.应用组织工程修复脊髓损伤逐渐成为研究的热点,应用支架材料防止瘢痕形成,诱导细胞再生十分重要.纳米技术以其独特的优势使支架材料的性能得到很大的改善,纳米支架的优势明显.通过纳米技术可制备出新型支架材料,纳米支架还能作为良好的药物载体,通过改善纳米支架的性能对其表面种子细胞的黏附、增殖、分化等生物行为产生有利的影响,从而促进组织再生及功能修复,在脊髓损伤的修复中取得良好的效果.对近年来纳米脊髓组织工程支架的研究进展进行综述,以期为相关领域的研究提供参考.
척수손상시의학계급수해결적난제.응용조직공정수복척수손상축점성위연구적열점,응용지가재료방지반흔형성,유도세포재생십분중요.납미기술이기독특적우세사지가재료적성능득도흔대적개선,납미지가적우세명현.통과납미기술가제비출신형지가재료,납미지가환능작위량호적약물재체,통과개선납미지가적성능대기표면충자세포적점부、증식、분화등생물행위산생유리적영향,종이촉진조직재생급공능수복,재척수손상적수복중취득량호적효과.대근년래납미척수조직공정지가적연구진전진행종술,이기위상관영역적연구제공삼고.
Spinal cord injury is a difficult medical problem and need to be solved urgently.Application of tissue engineering to repair spinal cord injury has gradually become a hot spot.It is important to prevent the development of scar tissue while inducing cells' regeneration by using scaffold.Nanotechnology has improved the performance of scaffold because of its superiority.Nanoscaffold has obvious advantages compared with the traditional scaffolds.New scaffold materials can be obtained by nanotechnology.Nanoscaffold can also serve as a good drug carrier,and it may have beneficial effects on biological behaviors of seed cells on its surface,such as differentiation,proliferation and migration,which may promote tissue regeneration and functional recovery and get good results in repairment of spinal cord injury.This article summarized the research progress in recent years in nano spinal cord engineering scaffolds in order to provide a reference for research in related fields.