CAJ | 학술논문

近年来,作为药剂学研究热点领域之一的靶向给药系统受到越来越多的关注.然而,这些抗肿瘤靶向载药运输系统存在诸多缺点如靶向效率低等而限制其在临床上的应用,提高肿瘤靶向效率已成为纳米药物研发和临床应用的瓶颈问题.因此,迫切需要设计并开发新型靶向药物递送载体.最近研究表明,间充质干细胞(MSCs)具有肿瘤趋向性和可迁移等特点,这些特点使得它们能够作为理想的抗肿瘤靶向药物递送载体来治疗实体瘤和转移瘤.综述了利用间充质干细胞作为肿瘤治疗的靶向药物递送载体的研究进展,概述了该系统存在的问题和挑战,并提出了针对这些问题的解决方法.
근년래,작위약제학연구열점영역지일적파향급약계통수도월래월다적관주.연이,저사항종류파향재약운수계통존재제다결점여파향효솔저등이한제기재림상상적응용,제고종류파향효솔이성위납미약물연발화림상응용적병경문제.인차,박절수요설계병개발신형파향약물체송재체.최근연구표명,간충질간세포(MSCs)구유종류추향성화가천이등특점,저사특점사득타문능구작위이상적항종류파향약물체송재체래치료실체류화전이류.종술료이용간충질간세포작위종류치료적파향약물체송재체적연구진전,개술료해계통존재적문제화도전,병제출료침대저사문제적해결방법.
In recent years,targeted drug delivery system as one of the hottest areas in pharmaceutical research has received more and more attention.However,the targeted anti-tumor drug delivery system has many shortcomings including low targeted efficiency which limit its clinical application.Elevating tumor targeting efficiency has become the bottleneck of nano-drug development and clinical application.Therefore,it is urgent to design and develop novel targeted drug delivery vehicle.Recent studies showed that mesenchymal stem cells (MSCs) have characters of tumor tropism and migration,which make them as ideal targeted anti-tumor drug delivery carriers for the treatment of solid and metastatic tumors.This paper reviews the progress in using MSCs as targeted anti-tumor drug delivery carrier,recapitulates the problems and challenges of the system,and proposes a solution for these problems.