CAJ | 학술논문

生物材料在骨再生治疗及组织工程领域的应用日益广泛.基于不同的构成、大小及形状,纳米颗粒与骨细胞之间的作用具有显著的独特性.因此,详细地分析纳米颗粒对细胞功能的作用,有利于选择更适于促进骨再生的材料.通过系统回顾纳米颗粒对间充质干细胞(MSCs)、成骨细胞及破骨细胞的作用,发现纳米颗粒对这些骨相关细胞具有十分重要的影响.其在骨缺损填充、作为药物和基因运输载体等方面具有广阔的应用前景,是促进骨再生及治疗骨疾病的良好选择.
생물재료재골재생치료급조직공정영역적응용일익엄범.기우불동적구성、대소급형상,납미과립여골세포지간적작용구유현저적독특성.인차,상세지분석납미과립대세포공능적작용,유리우선택경괄우촉진골재생적재료.통과계통회고납미과립대간충질간세포(MSCs)、성골세포급파골세포적작용,발현납미과립대저사골상관세포구유십분중요적영향.기재골결손전충、작위약물화기인운수재체등방면구유엄활적응용전경,시촉진골재생급치료골질병적량호선택.
Biomaterials are commonly applied in regenerative therapy and tissue engineering in bone.Generally,nanoparticles interact distinctively with bone cells and tissue,depending on their com-position,size,and shape.Therefore,detailed analyses of nanoparticle effects on cellular functions have been performed to select the most suitable candidates for supporting bone regeneration.This review will highlight potential nanoparticle applications in bone.We found that mesenchymal stem cells (MSCs) display exceptional regenerative potential.The delivery of genetic material with nanoparticulate carriers offers the possibility of overcoming certain disadvantages of standard protein delivery approaches.Moreover,nanoparticles are already clinically applied in cancer treatment.Thus,corresponding efforts could lead to new therapeutic strategies to improve bone regeneration or to treat bone disorders.