国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2013年
5期
257-260
,共4页
赵燕娟%李荣华%董晓曦%殷恺
趙燕娟%李榮華%董曉晞%慇愷
조연연%리영화%동효희%은개
低能量激光%牙周炎%碱性成纤维细胞生长因子%细胞因子
低能量激光%牙週炎%堿性成纖維細胞生長因子%細胞因子
저능량격광%아주염%감성성섬유세포생장인자%세포인자
Low-level lasers%Periodontitis%b-FGF%Cytokines
目的 观察牙周基础治疗结合低能量激光照射疗法(LLLT)对牙周炎的治疗效果.方法 选择18例慢性牙周炎患者共80颗患牙,左右对称,随机确定一侧为实验组(基础治疗加激光),对侧牙为对照组(基础治疗).口腔卫生宣教和龈上洁治后1周为基线,治疗1周、4周和12周时,检测龈沟出血指数(SBI)、牙周探诊深度(PD)、临床附着丧失(CAL);收集2组的龈沟液,用ELISA法检测其中的碱性成纤维细胞生长因子(b-FGF)、IL-1β和IL-8的水平,并比较其变化.结果 SBI、PD的变化:1周时仅SBI实验组与基线相比,差异具有统计学意义(P＜0.05);4周时实验组和对照组分别与基线相比,其差异均具有统计学意义(P＜0.05);12周时对照组与基线相比,差异有统计学意义(P＜0.05),实验组差异更为显著(P＜0.01).2组SBI均在PD≥6 mm时下降最明显.CAL的改善:4周时实验组与基线相比,差异具有统计学意义(P＜0.05);12周时与基线相比,对照组差异具有统计学意义(P＜0.05),实验组效果更为显著(P＜0.01).b-FGF的水平:治疗后与基线相比,实验组持续上升,对照组先下降后回升到基线水平,12周时2组相比,差异具有统计学意义(P＜0.05).IL-1β和IL-8的变化:12周时,实验组的变化优于对照组,2组间相比,其差异无统计学意义(P＞0.05).结论 LLLT通过降低患者SBI、减少PD、改善CAL和增加龈沟液b-FGF的水平等途径可加速牙周组织的愈合.
目的 觀察牙週基礎治療結閤低能量激光照射療法(LLLT)對牙週炎的治療效果.方法 選擇18例慢性牙週炎患者共80顆患牙,左右對稱,隨機確定一側為實驗組(基礎治療加激光),對側牙為對照組(基礎治療).口腔衛生宣教和齦上潔治後1週為基線,治療1週、4週和12週時,檢測齦溝齣血指數(SBI)、牙週探診深度(PD)、臨床附著喪失(CAL);收集2組的齦溝液,用ELISA法檢測其中的堿性成纖維細胞生長因子(b-FGF)、IL-1β和IL-8的水平,併比較其變化.結果 SBI、PD的變化:1週時僅SBI實驗組與基線相比,差異具有統計學意義(P＜0.05);4週時實驗組和對照組分彆與基線相比,其差異均具有統計學意義(P＜0.05);12週時對照組與基線相比,差異有統計學意義(P＜0.05),實驗組差異更為顯著(P＜0.01).2組SBI均在PD≥6 mm時下降最明顯.CAL的改善:4週時實驗組與基線相比,差異具有統計學意義(P＜0.05);12週時與基線相比,對照組差異具有統計學意義(P＜0.05),實驗組效果更為顯著(P＜0.01).b-FGF的水平:治療後與基線相比,實驗組持續上升,對照組先下降後迴升到基線水平,12週時2組相比,差異具有統計學意義(P＜0.05).IL-1β和IL-8的變化:12週時,實驗組的變化優于對照組,2組間相比,其差異無統計學意義(P＞0.05).結論 LLLT通過降低患者SBI、減少PD、改善CAL和增加齦溝液b-FGF的水平等途徑可加速牙週組織的愈閤.
목적 관찰아주기출치료결합저능량격광조사요법(LLLT)대아주염적치료효과.방법 선택18례만성아주염환자공80과환아,좌우대칭,수궤학정일측위실험조(기출치료가격광),대측아위대조조(기출치료).구강위생선교화간상길치후1주위기선,치료1주、4주화12주시,검측간구출혈지수(SBI)、아주탐진심도(PD)、림상부착상실(CAL);수집2조적간구액,용ELISA법검측기중적감성성섬유세포생장인자(b-FGF)、IL-1β화IL-8적수평,병비교기변화.결과 SBI、PD적변화:1주시부SBI실험조여기선상비,차이구유통계학의의(P＜0.05);4주시실험조화대조조분별여기선상비,기차이균구유통계학의의(P＜0.05);12주시대조조여기선상비,차이유통계학의의(P＜0.05),실험조차이경위현저(P＜0.01).2조SBI균재PD≥6 mm시하강최명현.CAL적개선:4주시실험조여기선상비,차이구유통계학의의(P＜0.05);12주시여기선상비,대조조차이구유통계학의의(P＜0.05),실험조효과경위현저(P＜0.01).b-FGF적수평:치료후여기선상비,실험조지속상승,대조조선하강후회승도기선수평,12주시2조상비,차이구유통계학의의(P＜0.05).IL-1β화IL-8적변화:12주시,실험조적변화우우대조조,2조간상비,기차이무통계학의의(P＞0.05).결론 LLLT통과강저환자SBI、감소PD、개선CAL화증가간구액b-FGF적수평등도경가가속아주조직적유합.
Objective The purpose of this study was to explore the efficacy of low level laser treatment (LLLT) combined with initial periodontal therapy in treating chronic periodontits.Methods Eighteen patients with chronic periodontitis were randomly treated in a spit-mouth design with combination of laser (808 nm,80 mW) treatment with scaling and root planing (experimental) or with scaling and root planing alone (contol) after OHI and supragingival cleaning.Clinical parameters of sulcus bleeding index (SBI),periodontal probing depth (PD) and clinical attachment loss (CAL) of both sides were recorded and gingival crevicular fluid samples were collected at baseline and 1,4,12 weeks after the treatment.GCF samples were analyzed for b-FGF,IL-1β,IL-8 level using ELISA assay.Results For the change of SBI and PD,only SBI in the experimental group experienced significant reduction (P＜0.05) at 1 week compared with baseline (P＜0.05),and the reduction in both groups were statistically significant (P＜0.05) at 4 weeks.The same situation occurred while both experimental groups made more significant difference (P＜0.01) at 12 weeks.The reduction of SBI was obvious in both groups when the PD was more than 6 mm.For CAL,the experimental group showed signs of improvement (P＜0.05) at 4 weeks; both groups indicated improvement (P＜0.05),while the experimental was more significant (P＜0.01) at 12 weeks.For the levels of b-FGF,it showed steady rise after treatment in experimental group,while it went up to the baseline after falling in control group.At 12 weeks,there were statistical significance of differences between two groups (P＜0.05).The changes of IL-1β and IL-8,in the experimental group showed better results than that in control group,while the difference between two groups was not significant (P＞0.05).Conclusion LLLI can accelerate the healing of periodontal tissue by reducing the SBI,decreasing the PD,improving the CAL and increasing levels of b-FGF in the GCF of the patients.
