CAJ | 학술논문

目的研究荧光光谱法检测癌光啉在BN大鼠体内的药代动力学.方法 BN大鼠尾静脉注射5 mg/kg体质量的癌光啉,于给药后的10 min、30 min、1h、2h、4h、8h、24 h、48 h和72 h眼眶后静脉丛取血,以荧光光谱仪测定大鼠血浆中癌光啉浓度,用DNS2.0处理血药浓度-时间数据,分析房室模型,得到最佳房室模型和药代动力学参数.结果 BN大鼠静脉注射的时量曲线符合三室模型.主要药代动力学参数:t1/2a=0.096 h,t1/2β=1.299 h,t1/2=19.387 h,V1=0.259 L/kg,A UC=15.263 mg/(L·h).结论荧光光谱法检测光敏剂血药浓度操作简单,耗时短,灵敏度和特异性高.癌光啉在BN大鼠体内吸收快,起效快,无蓄积现象.
목적 연구형광광보법검측암광람재BN대서체내적약대동역학.방법 BN대서미정맥주사5 mg/kg체질량적암광람,우급약후적10 min、30 min、1h、2h、4h、8h、24 h、48 h화72 h안광후정맥총취혈,이형광광보의측정대서혈장중암광람농도,용DNS2.0처리혈약농도-시간수거,분석방실모형,득도최가방실모형화약대동역학삼수.결과 BN대서정맥주사적시량곡선부합삼실모형.주요약대동역학삼수:t1/2a=0.096 h,t1/2β=1.299 h,t1/2=19.387 h,V1=0.259 L/kg,A UC=15.263 mg/(L·h).결론 형광광보법검측광민제혈약농도조작간단,모시단,령민도화특이성고.암광람재BN대서체내흡수쾌,기효쾌,무축적현상.
Objective To investigate the pharmacokinetic characteristics of PSD-007 in BN rats.Methods Blood of the BN rats was collected from the inner canthus after iv administration of PSD-007,and the plasma drug concentrations at different times were determined by fluorescent spectrometry.The best compartment model and the pharmacolinetic were calculated by the software of DNS 2.0.Results The elimination process of PSD-007 fitted three-compartment open model after iv administration.The principal pharmacokinetic parameters were t1/2α=0.096 h,t1/2β=1.299 h,t12γ=19.387 h,V1=0.259 L/kg,A UC=15.263 mg/(L ·h).Conclusions The sensitivity of fluorescent spectrometry was high and the operation is sinple and the progress is short.PSD-007 has fast absorption,quick effect and elimination without accumulation phenomenon.