CAJ | 학술논문

基于荧光分子断层成像(FMT)的多模成像系统已广泛应用于动物实验研究,它将现有的其他成像模态与FMT系统相融合,实现同时对被测生物解剖学结构、生理学功能和分子或细胞水平生物学活动的在体成像.首先介绍了单模FMT系统的发展历史和现状,并介绍了国内外基于FMT的多模系统的研究进展,着重介绍了文献报道的典型的FMT/CT、FMT/MRI和FMT/放射性核素成像系统的系统组成、工作原理、性能特点及实验应用.对基于FMT的多模成像系统的发展进行了展望.
기우형광분자단층성상(FMT)적다모성상계통이엄범응용우동물실험연구,타장현유적기타성상모태여FMT계통상융합,실현동시대피측생물해부학결구、생이학공능화분자혹세포수평생물학활동적재체성상.수선개소료단모FMT계통적발전역사화현상,병개소료국내외기우FMT적다모계통적연구진전,착중개소료문헌보도적전형적FMT/CT、FMT/MRI화FMT/방사성핵소성상계통적계통조성、공작원리、성능특점급실험응용.대기우FMT적다모성상계통적발전진행료전망.
Multi-modality imaging system based on fluorescence molecular tomography (FMT) has been widely used in animal studies.It combines FMT with other imaging modalities,which realizes the imaging of anatomical structure,physiological function and biological activities on molecular or cellular levels of small animal in vivo at the same time.This review gives an introduction to the history and current research status of singlemodality FMT system,introduces the developments of multi-modality system based on FMT,especially the system setup,working principle,performance and application of FMT/CT,FMT/MRI and FMT/radionuclide imaging.The prospects of multi-modality imaging system based on FMT are discussed.