CAJ | 학술논문

在生物材料的相容性研究中,蛋白质与材料表面的相互作用极其关键,一直是研究的重点之一.一般认为血细胞是与吸附在材料表面的蛋白质分子层相互作用,而不是与材料表面直接接触,因此蛋白质对于细胞的调控和诱导起到了关键作用.探索控制蛋白吸附行为的分子机制,从而调控细胞的应答为设计生物材料提供了思路.综述了蛋白质与生物材料相互作用的研究进展,展望了未来的研究方向.
재생물재료적상용성연구중,단백질여재료표면적상호작용겁기관건,일직시연구적중점지일.일반인위혈세포시여흡부재재료표면적단백질분자층상호작용,이불시여재료표면직접접촉,인차단백질대우세포적조공화유도기도료관건작용.탐색공제단백흡부행위적분자궤제,종이조공세포적응답위설계생물재료제공료사로.종술료단백질여생물재료상호작용적연구진전,전망료미래적연구방향.
The study of protein-surface interactions represents one of the most important topics in the field of biomaterials.It is believed that blood cells do not actually contact the biomaterial surface directly,but rather interact with the molecular structure of the adsorbed protein layer.Therefore,protein plays a key role in regulation and induction of cells.It provides ideas for biomaterials designing that exploring the molecular mechanism of controlling protein adsorption and regulating cell response.This paper reviews the research progress of the interactions of protein and surfaces,and prospects the future research direction.