CAJ | 학술논문

干细胞具有自我更新和分化能力,其中自我更新与在持续增殖的细胞周期保持其多能性密切相关.因此,干细胞的周期改变和调节方式均能从多方面影响其多能性,如细胞周期蛋白在干细胞多能性调节中发挥着重要作用,其中,周期蛋白依赖性激酶(CDK)等对干细胞的增殖和分化具有举足轻重的影响;S期是遗传和表观遗传学调控影响干细胞多能性的重要时期;转录因子Myc平衡着干细胞多能性和定向分化能力等.从CDK及Myc分子对干细胞周期的调节和对多能性的影响等方面进行综述和探讨,以促进细胞周期对干细胞相关调控机制的研究,为再生医学后续干细胞的深入研究提供理论依据.
간세포구유자아경신화분화능력,기중자아경신여재지속증식적세포주기보지기다능성밀절상관.인차,간세포적주기개변화조절방식균능종다방면영향기다능성,여세포주기단백재간세포다능성조절중발휘착중요작용,기중,주기단백의뢰성격매(CDK)등대간세포적증식화분화구유거족경중적영향;S기시유전화표관유전학조공영향간세포다능성적중요시기;전록인자Myc평형착간세포다능성화정향분화능력등.종CDK급Myc분자대간세포주기적조절화대다능성적영향등방면진행종술화탐토,이촉진세포주기대간세포상관조공궤제적연구,위재생의학후속간세포적심입연구제공이론의거.
Stem cells have self-renewal and differentiation potential.Cyclin-dependent kinase (CDK) plays an important role in promoting pluripotency and self-renewal.The crucial activity of S-phase,DNA replication,presents a unique opportunity during the cell cycle for the genetic and epigenetic regulation that may be involved in stabilizing the pluripotent state.It is also clear that Myc acts to coordinate both the cell cycle and the pluripotency transcription network in stem cells.Here we review the regulating mechanisms of stem cell cycles and pluripotency by CDK and Myc to help researchers obtain a better understanding of mutual regulation of the cell cycle and the pluripotent state by CDK and Myc which may be exploited in regenerative medicine.