CAJ | 학술논문

目的应用超声射频信号技术评价高甘油三脂血症(HTG)患者颈动脉内中膜厚度及弹性功能早期改变的临床意义.方法将48例HTG患者(甘油三脂≥1.8 mmol/L)作为受试组,应用超声射频信号血管内中膜厚度定量分析(QIMT)及动脉僵硬度定量分析(QAS)技术,观察颈动脉内中膜厚度(IMT)及弹性指标的改变,包括颈动脉内径(D)、管壁扩张系数(DC)、顺应系数(CC)、弹性系数(α)、弹性系数(β)及脉搏波传播速度(PWV);并将50例健康人作为对照组.分析上述参数在2组间的差别及弹性指标之间的相关性.结果 HTC组的2侧颈动脉IMT、α、β及PWV的弹性指标均高于对照组,DC、CC较对照组降低,其差异有统计学意义(P＜0.05).组内2侧颈动脉弹性指标之间存在差异,CCL＞CCR,αL＞αR,βL＞βR,PWVL＞PWVR.CC与α、β、PWV呈负相关(P＜0.05),α、β、PWV之间呈正相关(P＜0.05).2组颈动脉内径(D)比较差异无统计学意义(P＞0.05).结论动脉弹性异常早于形态学的改变,应用超声射频信号技术能提供HTG患者早期颈总动脉结构和弹性功能改变的信息,对其临床早期诊疗具有一定意义.
목적 응용초성사빈신호기술평개고감유삼지혈증(HTG)환자경동맥내중막후도급탄성공능조기개변적림상의의.방법 장48례HTG환자(감유삼지≥1.8 mmol/L)작위수시조,응용초성사빈신호혈관내중막후도정량분석(QIMT)급동맥강경도정량분석(QAS)기술,관찰경동맥내중막후도(IMT)급탄성지표적개변,포괄경동맥내경(D)、관벽확장계수(DC)、순응계수(CC)、탄성계수(α)、탄성계수(β)급맥박파전파속도(PWV);병장50례건강인작위대조조.분석상술삼수재2조간적차별급탄성지표지간적상관성.결과 HTC조적2측경동맥IMT、α、β급PWV적탄성지표균고우대조조,DC、CC교대조조강저,기차이유통계학의의(P＜0.05).조내2측경동맥탄성지표지간존재차이,CCL＞CCR,αL＞αR,βL＞βR,PWVL＞PWVR.CC여α、β、PWV정부상관(P＜0.05),α、β、PWV지간정정상관(P＜0.05).2조경동맥내경(D)비교차이무통계학의의(P＞0.05).결론 동맥탄성이상조우형태학적개변,응용초성사빈신호기술능제공HTG환자조기경총동맥결구화탄성공능개변적신식,대기림상조기진료구유일정의의.
Objective To evaluate the clinical value of early alterations of carotid arterial intima-media thickness (IMT) and elastic function in patients with hypertriglyceridemia (HTG) using ultrasound radio-frequency technique.Methods 48 patients (triglyceride value ≥ 1.8 mmol/L) were chosen as HTG group.Quantitative intimamedia thickness (QIMT) and quantitative arterial stiffness (QAS) techniques were used to observe the alterations of carotid arterial IMT and elastic index,including diameter of carotid artery (D),distensibility coefficient (DC),compliance coefficient (CC),elasticity coefficient (α),elasticity coefficient (β) and pulse wave velocity (PWV).50 healthy subjects were recruited in control group.Differences of the above-mentioned parameters were analyzed,as well as the elastic index connections between the two groups.Results IMT,α,β,and PWV index of bilateral carotid arteries in HTG group was higher than that of the control group,while the DC and CC index was lower,and the differences was statistically significant (P＜0.05).Within the groups there were differences between the elastic indexes of bilateral carotid arteries.In control group and the HTG group:CCL＞CCR,αL＞αR,βL＞βR,PWVL＞PWVR.CC was negatively correlated to α,β and PWV (P＜0.05).Meanwhile,there was positive correlation among α,β and PWV (P＜0.05).The differences of D between two groups had no statistical significance (P＞0.05).Conclusions The abnormity of arterial occurs earlier than the morphological change,while the ultrasound radio-frequency technique can provide information of earlier alteration of common carotid arteries structure and elastic function in patients with HTG,which is a significant method of testing early alteration of carotid elastic in patients with HTG.