CAJ | 학술논문

随着药物载体技术的快速发展,将生物活性大分子输送至特定靶细胞治疗各种疾病日益受到关注.虽然生物活性大分子在一些疾病治疗中取得了一定疗效,但靶细胞微环境对其最终疗效影响较大.许多疾病和损伤扰乱了正常细胞外基质(ECM)的体系结构、细胞对ECM的黏附及之后的细胞活动.因此,ECM构建的细胞微环境对维持机体平衡、组织再生及修复起着关键性作用.鉴于此,就ECM构建的细胞微环境对生物活性大分子疗效的影响作一综述,为载药系统的设计及药物合成等提供一定的理论基础.
수착약물재체기술적쾌속발전,장생물활성대분자수송지특정파세포치료각충질병일익수도관주.수연생물활성대분자재일사질병치료중취득료일정료효,단파세포미배경대기최종료효영향교대.허다질병화손상우란료정상세포외기질(ECM)적체계결구、세포대ECM적점부급지후적세포활동.인차,ECM구건적세포미배경대유지궤체평형、조직재생급수복기착관건성작용.감우차,취ECM구건적세포미배경대생물활성대분자료효적영향작일종술,위재약계통적설계급약물합성등제공일정적이론기출.
Currently,with the rapid development of drug delivery technologies,more and more efforts are taken into the efficient therapies for various diseases by delivering biologically-active macromolecules into the target cells directly.Although a certain number of positive treatment results were obtained from the therapies by using the biomacromolecules to cure some diseases,the microenvironment around the target cell still has a great influence on the final treatment effect.Since many diseases and injuries interfere the normal architecture of the extracellular matrix (ECM),the cell adhesion to ECM and the subsequent cellular activities,the normal microenvironment of the cell plays a critical role in maintaining body balance,tissue regeneration and repair.Given these points,this paper reviews the effects of the cellular microenvironment constructed by ECM on the efficacy of bioactive macromolecules,and provides a theoretical basis for future drug design and synthesis of pharmaceuticals.