CAJ | 학술논문

目的制备聚己内酯(PCL)长效药物缓释制剂,优化药物缓释效果,并研究PCL埋植剂的药物通透性.方法合成分子质量为(8～16)×104 u含有普朗尼克F68的PCL,用挤出法制备不同壁厚的PCL长效缓释埋植剂.将左炔诺孕酮(LNG)装入PCL管封装,制成LNG药囊.通过高效液相色谱法测定LNG的释放效果,考察PCL的分子质量及PCL管壁厚度对LNG通透性的影响.结果当PCL分子质量为(8～16)×104u时,对LNG通透性无显著影响.PCL管壁厚在0.20～0.40 mm时,对LNG通透性亦无显著影响;当壁厚小于0.15 mm时,LNG通透性显著提高.结论 PCL埋植剂对LNG具有通透性,可通过改变PCL管壁厚度增加药物通透性.
목적제비취기내지(PCL)장효약물완석제제,우화약물완석효과,병연구PCL매식제적약물통투성.방법 합성분자질량위(8～16)×104 u함유보랑니극F68적PCL,용제출법제비불동벽후적PCL장효완석매식제.장좌결낙잉동(LNG)장입PCL관봉장,제성LNG약낭.통과고효액상색보법측정LNG적석방효과,고찰PCL적분자질량급PCL관벽후도대LNG통투성적영향.결과 당PCL분자질량위(8～16)×104u시,대LNG통투성무현저영향.PCL관벽후재0.20～0.40 mm시,대LNG통투성역무현저영향;당벽후소우0.15 mm시,LNG통투성현저제고.결론 PCL매식제대LNG구유통투성,가통과개변PCL관벽후도증가약물통투성.
Objective To prepare polycaprolactone (PCL) implant with long-term sustained release,optimize the drug delivery effect and observe the permeability of PCL for drug.Methods PCL implant with average molecular weight of (8-16)×104 u were synthesized and extruded into tubes.The tubular capsules were filled with levonorgestrel (LNG),closed at both ends.The drug release of PCL implant was measured by HPLC.The drug permeability of PCL implant was evaluated with different molecular weight and thickness.Results The molecular weight of (8-16)×104 u showed no effect on the permeability of PCL implant for LNG.The thickness of 0.20-0.40 mm of PCL membranes showed no effect on the permeability for LNG.The PCL membranes with the thickness of less than 0.15 mm had the higher permeability than those with the thickness of 0.20-0.40 mm.Conclusions The PCL implant is permeable for LNG and the permeability can be increased by decreasing the thickness of membrane.