CAJ | 학술논문

目的初步研究光动力疗法(PDT)对实验性变应性鼻炎(AR)的治疗作用.方法随机将18只新西兰兔均分为实验组A、阴性对照组B、空白对照组C共3组,采用卵清蛋白(OVA)致敏A、B2组兔制作动物AR模型,A组予以PDT治疗,B、C2组予以自然光处理,观察治疗前后症状及体征的变化,在光镜和透射电镜下观察鼻黏膜的变化.结果与B组相比,A组兔经PDT治疗后,与AR相关症状和体征明显改善,光镜及透射电镜观察显示,炎性细胞明显减少,黏膜结构逐渐恢复,21 d后,A组与C组相比喷嚏次数、抓鼻次数及鼻分泌量差异无统计学意义(P＞0.05),光镜及透射电镜下观察黏膜结构表现基本相似.结论 PDT对实验性AR有一定的治疗作用,为PDT用于AR定点治疗的临床应用提供了实验基础.
목적 초보연구광동력요법(PDT)대실험성변응성비염(AR)적치료작용.방법 수궤장18지신서란토균분위실험조A、음성대조조B、공백대조조C공3조,채용란청단백(OVA)치민A、B2조토제작동물AR모형,A조여이PDT치료,B、C2조여이자연광처리,관찰치료전후증상급체정적변화,재광경화투사전경하관찰비점막적변화.결과 여B조상비,A조토경PDT치료후,여AR상관증상화체정명현개선,광경급투사전경관찰현시,염성세포명현감소,점막결구축점회복,21 d후,A조여C조상비분체차수、조비차수급비분비량차이무통계학의의(P＞0.05),광경급투사전경하관찰점막결구표현기본상사.결론 PDT대실험성AR유일정적치료작용,위PDT용우AR정점치료적림상응용제공료실험기출.
Objective To preliminarily investigate the therapeutic effect of photodynamic therapy (PT) treating allergic rhinitis (AR).Methods Eighteen New Zealand rabbits were randomly divided into 3 groups,experimental group A,negative control group B and blank control group C.Rabbits of A and B groups were sensitized with ovalbumin (OVA) to get animal AR model.Group A was treated with PDT while group B and C were applied with natural light treatment.Symptoms and signs before and after treatment were compared and the change of nasal mucosa was observed with light microscope and transmission electron microscope.Results After PDT treatment,group A rabbits' AR symptoms and signs were improved significantly compared to group B,light microscope and transmission electron microscope observation showed that the number of inflammatory cells of group A rabbits decreased significantly and the mucosal structure returned to normal after PDT treatment.After 21 d,as compared with group C,the differences of the times of sneezing and scratching and nasal secretion had no statistical significance (P＞0.05).Conclusions PDT has certain therapeutic effect in experimental AR treatment,which can be used in AR treatment after consummating its therapeutic mechanism.