国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2014年
5期
299-302
,共4页
郭芳%崔洁%张红雨%张忠太%田蓉蓉%原凌
郭芳%崔潔%張紅雨%張忠太%田蓉蓉%原凌
곽방%최길%장홍우%장충태%전용용%원릉
儿科PET/CT%采集时间%18F-FDG活度
兒科PET/CT%採集時間%18F-FDG活度
인과PET/CT%채집시간%18F-FDG활도
Pediatric PET/CT%Acquisition durations%18F-FDG activity
目的 目前儿科β-2-[F]氟-2-脱氧-D-葡萄糖(18F-FDG)剂量和采集时间一般是按照成人的参数推算出来.本研究目的是对在不影响图像诊断质量的前提下,行儿科正电子发射型计算机断层显像(PET)/CT检查时,缩短采集时间或降低18F-FDG注射用量的可行性进行初步研究.方法 对36例患者(体质量为13～89 kg,平均体质量(46.51±5.63) kg;年龄3～14岁,平均年龄(9.22±3.16)岁)行36次全身18F-FDG PET/CT扫描,按照5.3 MBq/kg(0.14 mCi/kg)计算注射18F-FDG,采用VIP record采集模式,180 s/视野(FOV);对于每次检查,VIP record记录的数据按照采集时间的减少(160、140、120、100、80、60 s/FOV的数据按照180 s/FOV的数据来模拟计算),分别被缩减以形成不同采集时间下的图像.随机挑选168幅PET图像以及相对应的CT图像,通过6位影像学专家阅片,对全身存在的病灶进行分析,分别对颈部、胸部、腹部、骨等部位病灶的符合率进行对比,并对主观可信度以及客观准确度进行全面评估.结果 所有检查均以最大采集时间作为分级标准和检查准确度的参考标准.对于体质量＞30 kg的受检者,当采集时间＞120 s/FOV时,所有病灶均可以检测出来,采用120 s/FOV以下的参数进行采集时,病灶检测准确度会大大降低;对于体质量＜30 kg的受检者,当采集时间＞140s/FOV时,所有病灶均可以检测出来,采用140 s/FOV以下的参数进行采集时,病灶检测准确度会大大降低.结论 应用GE Discovery STE PET/CT行儿科检查时,采用减少18F-FDG用量替代减少采集时间,如果采用180s/FOV时,对于体质量＞30 kg的受检者,18F-FDG的用量可降低33.33％;对于体质量＜30 kg的受检者,18F-FDG的用量可降低22.22％,而且不会损失图像诊断质量.所需扫描全部时间的减少意味着可以减少运动伪影,提高受检者舒适度以及减少所需镇静的时间;另外,通过减少18F-FDG用量,还可降低受辐射的风险.
目的 目前兒科β-2-[F]氟-2-脫氧-D-葡萄糖(18F-FDG)劑量和採集時間一般是按照成人的參數推算齣來.本研究目的是對在不影響圖像診斷質量的前提下,行兒科正電子髮射型計算機斷層顯像(PET)/CT檢查時,縮短採集時間或降低18F-FDG註射用量的可行性進行初步研究.方法 對36例患者(體質量為13～89 kg,平均體質量(46.51±5.63) kg;年齡3～14歲,平均年齡(9.22±3.16)歲)行36次全身18F-FDG PET/CT掃描,按照5.3 MBq/kg(0.14 mCi/kg)計算註射18F-FDG,採用VIP record採集模式,180 s/視野(FOV);對于每次檢查,VIP record記錄的數據按照採集時間的減少(160、140、120、100、80、60 s/FOV的數據按照180 s/FOV的數據來模擬計算),分彆被縮減以形成不同採集時間下的圖像.隨機挑選168幅PET圖像以及相對應的CT圖像,通過6位影像學專傢閱片,對全身存在的病竈進行分析,分彆對頸部、胸部、腹部、骨等部位病竈的符閤率進行對比,併對主觀可信度以及客觀準確度進行全麵評估.結果 所有檢查均以最大採集時間作為分級標準和檢查準確度的參攷標準.對于體質量＞30 kg的受檢者,噹採集時間＞120 s/FOV時,所有病竈均可以檢測齣來,採用120 s/FOV以下的參數進行採集時,病竈檢測準確度會大大降低;對于體質量＜30 kg的受檢者,噹採集時間＞140s/FOV時,所有病竈均可以檢測齣來,採用140 s/FOV以下的參數進行採集時,病竈檢測準確度會大大降低.結論 應用GE Discovery STE PET/CT行兒科檢查時,採用減少18F-FDG用量替代減少採集時間,如果採用180s/FOV時,對于體質量＞30 kg的受檢者,18F-FDG的用量可降低33.33％;對于體質量＜30 kg的受檢者,18F-FDG的用量可降低22.22％,而且不會損失圖像診斷質量.所需掃描全部時間的減少意味著可以減少運動偽影,提高受檢者舒適度以及減少所需鎮靜的時間;另外,通過減少18F-FDG用量,還可降低受輻射的風險.
목적 목전인과β-2-[F]불-2-탈양-D-포도당(18F-FDG)제량화채집시간일반시안조성인적삼수추산출래.본연구목적시대재불영향도상진단질량적전제하,행인과정전자발사형계산궤단층현상(PET)/CT검사시,축단채집시간혹강저18F-FDG주사용량적가행성진행초보연구.방법 대36례환자(체질량위13～89 kg,평균체질량(46.51±5.63) kg;년령3～14세,평균년령(9.22±3.16)세)행36차전신18F-FDG PET/CT소묘,안조5.3 MBq/kg(0.14 mCi/kg)계산주사18F-FDG,채용VIP record채집모식,180 s/시야(FOV);대우매차검사,VIP record기록적수거안조채집시간적감소(160、140、120、100、80、60 s/FOV적수거안조180 s/FOV적수거래모의계산),분별피축감이형성불동채집시간하적도상.수궤도선168폭PET도상이급상대응적CT도상,통과6위영상학전가열편,대전신존재적병조진행분석,분별대경부、흉부、복부、골등부위병조적부합솔진행대비,병대주관가신도이급객관준학도진행전면평고.결과 소유검사균이최대채집시간작위분급표준화검사준학도적삼고표준.대우체질량＞30 kg적수검자,당채집시간＞120 s/FOV시,소유병조균가이검측출래,채용120 s/FOV이하적삼수진행채집시,병조검측준학도회대대강저;대우체질량＜30 kg적수검자,당채집시간＞140s/FOV시,소유병조균가이검측출래,채용140 s/FOV이하적삼수진행채집시,병조검측준학도회대대강저.결론 응용GE Discovery STE PET/CT행인과검사시,채용감소18F-FDG용량체대감소채집시간,여과채용180s/FOV시,대우체질량＞30 kg적수검자,18F-FDG적용량가강저33.33％;대우체질량＜30 kg적수검자,18F-FDG적용량가강저22.22％,이차불회손실도상진단질량.소수소묘전부시간적감소의미착가이감소운동위영,제고수검자서괄도이급감소소수진정적시간;령외,통과감소18F-FDG용량,환가강저수복사적풍험.
Objective Currently,pediatric 18F-FDG dose and acquisition durations are generally based on coarse extrapolation from adult guidelines.This study sought to determine whether shorter acquisition durations or a lower 18F-FDG injected activity could be used during pediatric 18F-FDG PET/CT examinations while maintaining diagnostic utility.Methods Thirty-six whole-body 18F-FDG PET/CT examinations were performed on 36 patients (weight,13-89 kg,(46.51±5.63) kg; age range,3-14 years old,(9.22±3.16) years old) with a weight-based injected activity (5.3 MBq/kg (0.144 mCi/kg)),fixed acquisition durations 180 S/FOV,VIP record acquisition mode using Discovery STE.For each examination,the Vip-mode data was truncated to form multiple datasets with shorter acquisition durations down to a minimum of 60 s/FOV (i.e.,60,80,100,120,140,160 s/FOV data were formed from single 180 s/FOV acquisition).168 image volumes were generated,randomized,and reviewed in a masked manner with corresponding CT image volumes by 6 radiologists.Overall,subjective adequacy and objective lesion detection accuracy by body region were evaluated.Results All examinations with maximum acquisition duration were graded as adequate and were used as the reference standard for detection accuracy.For patients more than 30 kg,when acquisition duration was more than 120 s/FOV,all PET/CT examinations were graded as adequate for clinical tasks,whereas,when acquisition duration was reduced to less than 120 s/FOV,lesion detection became less accurate.For patients less than 30 kg,lesion detection accuracy was perfect for acquisition times between 140 s/FOV and 180 s/FOV for all regions of the body.However,lesion detection became less accurate when imaging acquisition time was reduced less than 140 s/FOV.Conclusions When GE Discovery STE PET/CT was applied during pediatric PET/CT examination,using decreased acquisition times as a surrogate for 18F-FDG dose,18F-FDG dose can be reduced by approximately 33.33％ when patients weigh over 30 kg were scanned for 180 s/FOV.For patients less than 30 kg,18F-FDG dose can be reduced by approximately 22.22％ without losing diagnostic quality.Reduction of overall scan time potentially reduces motion artifacts,improves patient comfort,and decreases length of sedation.Alternatively,decreased 18F-FDG dose minimizes radiation risk.
