CAJ | 학술논문

骨组织通过正常成骨活动对自身进行修复,在局部血供不佳、软组织损伤、不稳定的固定或广泛的骨组织丢失情况下,都有可能导致骨折延迟愈合甚至骨不愈合等并发症的发生.目前自体骨移植治疗是金标准.由于自体骨移植存在诸多并发症,目前的关注点已经逐渐转向异体骨移植和骨替代治疗,细胞疗法有望成为替代自体骨移植促进骨修复的有效方法,此方法免去了骨移植造成的供体损伤,并可有效降低治疗的侵袭性.主要回顾目前使用的细胞移植治疗长骨骨折或骨缺损的主要方法.
골조직통과정상성골활동대자신진행수복,재국부혈공불가、연조직손상、불은정적고정혹엄범적골조직주실정황하,도유가능도치골절연지유합심지골불유합등병발증적발생.목전자체골이식치료시금표준.유우자체골이식존재제다병발증,목전적관주점이경축점전향이체골이식화골체대치료,세포요법유망성위체대자체골이식촉진골수복적유효방법,차방법면거료골이식조성적공체손상,병가유효강저치료적침습성.주요회고목전사용적세포이식치료장골골절혹골결손적주요방법.
When natural bone repair mechanisms fail,autologous bone grafting is the golden standard of cure.The osteogenic cells and bone matrix in the graft provide the osteo-inductive and osteo-conductive properties required for successful bone repair.MSC (mesenchymal stem cell)-based cell therapy holds promise for promoting bone repair.This paper reviews the current application of cell therapy in bone repair for humans,chiefly at long bone sites,to achieve either fracture healing or bone defect filling.