CAJ | 학술논문

腺苷酸活化蛋白激酶的激活可以抑制胆固醇、脂肪的合成,最近研究表明,腺苷酸活化蛋白激酶的激活也可抑制胆汁酸合成及促进胆盐输出泵的生成,说明腺苷酸活化蛋白激酶在调节胆汁酸代谢中起着重要作用.本文将从腺苷酸活化蛋白激酶激活途径、胆汁酸代谢、腺苷酸活化蛋白激酶活性对胆汁酸合成及转运等方面进行综述.
선감산활화단백격매적격활가이억제담고순、지방적합성,최근연구표명,선감산활화단백격매적격활야가억제담즙산합성급촉진담염수출빙적생성,설명선감산활화단백격매재조절담즙산대사중기착중요작용.본문장종선감산활화단백격매격활도경、담즙산대사、선감산활화단백격매활성대담즙산합성급전운등방면진행종술.
Adenosine monophosphate-activated protein kinase (AMPK) activation also can inhibit the synthesis of cholesterol and fat.Recent studies have shown that activation of AMPK can also inhibit the synthesis of bile acid and promote bile salt export pump' s generation.All of those illustrated that AMPK played an important role in regulating bile acid metabolism.This article will summarize the AMPK activation pathway,bile acid metabolism,AMPK activity in bile acid synthesis and transfer,and so on.