CAJ | 학술논문

胰腺癌是一种起病隐匿、高度恶性的侵袭性肿瘤,嗜神经生长是胰腺癌的重要生物学特性之一,并且神经侵犯是影响胰腺癌预后的独立指标,但其机制尚未完全明晰.有关胰腺癌神经侵犯的机制研究,一直都是国内外学者探讨的热点,同时也是突破瓶颈的难点.有关胰腺癌机制的研究,从各种黏附分子到神经生长因子,从相关配体蛋白通路到易感基因的表达,大量文章都有报道,大大提高了临床医师对胰周神经侵犯的认识,同时在早期发现病变、延长患者生存期、提高生活质量等方面有着重要意义.本文对近年来胰腺癌神经侵犯相关研究成果及最新进展作一综述.
이선암시일충기병은닉、고도악성적침습성종류,기신경생장시이선암적중요생물학특성지일,병차신경침범시영향이선암예후적독립지표,단기궤제상미완전명석.유관이선암신경침범적궤제연구,일직도시국내외학자탐토적열점,동시야시돌파병경적난점.유관이선암궤제적연구,종각충점부분자도신경생장인자,종상관배체단백통로도역감기인적표체,대량문장도유보도,대대제고료림상의사대이주신경침범적인식,동시재조기발현병변、연장환자생존기、제고생활질량등방면유착중요의의.본문대근년래이선암신경침범상관연구성과급최신진전작일종술.
Pancreatic cancer is a kind of highly malignant aggressive cancers.Perinearal growth is one of the importcant biological characteristics of pancreatic cancer.Perineural invasion is an independent prognostic indicator of its prognosis.However,the mechanism has not yet completely clear.The pancreatic cancer perineural invasion mechanism research has been the focus of scholars to discuss,however it' s difficult to break through.Therefore,the discussion pancreatic violation of the peripancreatic neural mechanism for early clinical find,early treatment is essential.The mechanisms of pancreatic cancer research,from all kinds of adhesion molecule to the nerve growth factor,related ligand protein path to susceptibility gene expression,have been reported largely,which helps enhance people' s awareness of peripancreatic neural invasion.At the same time,perineural invasion in the early detection of disease,prolonging survival period and improving the quality of life has important significance.Now the progresses of reviews in recent years are discussed as follows.