CAJ | 학술논문

胃肠道肿瘤是严重危害人类健康的疾病.据统计,全世界每年因胃癌死亡人数达70万,占所有恶性肿瘤死亡人数的1/10；结直肠癌发病率在所有恶性肿瘤中排第3位,在癌症引起的死亡病例中排第4位.目前胃肠道肿瘤主要依靠手术、化疗等治疗方法,但对已经发生远端转移的肿瘤却收效甚微.近年来,由于各种纳米粒子能理想地在体内传递各种物质并具有可调的表面化学靶向结构,使得它在胃肠道肿瘤的靶向治疗中显现出独特的优势.本文就纳米材料介导的胃肠道肿瘤靶向治疗进展作一概述.
위장도종류시엄중위해인류건강적질병.거통계,전세계매년인위암사망인수체70만,점소유악성종류사망인수적1/10；결직장암발병솔재소유악성종류중배제3위,재암증인기적사망병례중배제4위.목전위장도종류주요의고수술、화료등치료방법,단대이경발생원단전이적종류각수효심미.근년래,유우각충납미입자능이상지재체내전체각충물질병구유가조적표면화학파향결구,사득타재위장도종류적파향치료중현현출독특적우세.본문취납미재료개도적위장도종류파향치료진전작일개술.
Gastrointestinal tumors are the major disease that threaten human health.According to statistics,more than 700 000 people died every year because of gastric cancer,1/10 of all cancer mortality.Colorectal cancer incidence of malignant tumors,which ranked third,ranked fourth in cancer deaths.At now the treatment of gastrointestinal tunors mostly are operation,radiotherapy and chemnotherapy,but to spread of tumors,doctors still haven' t more better method.Nanoparticles have properties in the diagnosis and treatment of cancer,including their size-dependent properties,stability in solvent,ideal size for delivery within the body,and tunable surface chemistry for targeted delivery.Here,the author do an overview of nanoparticles in gastrointestinal tumors ablation.