CAJ | 학술논문

脑源性神经营养因子是酪氨酸蛋白激酶受体B的配体,两者结合促进酪氨酸蛋白激酶受体同源二聚体形成,激活酪氨酸激酶受体B活性,促进受体酪氨酸残基磷酸化,活化的酪氨酸蛋白激酶受体B顺序激活多种蛋白酶,将脑源性神经营养因子信号传至细胞核,产生各种生物学效应.越来越多的研究发现,脑源性神经营养因子和酪氨酸蛋白激酶受体B在恶性肿瘤中的表达高于肿瘤旁组织及正常组织,它们通过促进肿瘤的血管形成,抑制肿瘤的失巢凋亡,抵抗抗肿瘤因子等各种方式,促进肿瘤的生长、分化和转移.脑源性神经营养因子及酪氨酸蛋白激酶受体B与肿瘤的密切联系,为临床治疗提供了一个新的治疗策略,那就是通过靶向抑制脑源性神经营养因子及酪氨酸蛋白激酶受体B的表达,从而促进肿瘤细胞失巢凋亡,抑制生长,分化和转移,达到治疗肿瘤的目的.从目前的基础和临床的研究看来,这种治疗策略有很大的应用前景.
뇌원성신경영양인자시락안산단백격매수체B적배체,량자결합촉진락안산단백격매수체동원이취체형성,격활락안산격매수체B활성,촉진수체락안산잔기린산화,활화적락안산단백격매수체B순서격활다충단백매,장뇌원성신경영양인자신호전지세포핵,산생각충생물학효응.월래월다적연구발현,뇌원성신경영양인자화락안산단백격매수체B재악성종류중적표체고우종류방조직급정상조직,타문통과촉진종류적혈관형성,억제종류적실소조망,저항항종류인자등각충방식,촉진종류적생장、분화화전이.뇌원성신경영양인자급락안산단백격매수체B여종류적밀절련계,위림상치료제공료일개신적치료책략,나취시통과파향억제뇌원성신경영양인자급락안산단백격매수체B적표체,종이촉진종류세포실소조망,억제생장,분화화전이,체도치료종류적목적.종목전적기출화림상적연구간래,저충치료책략유흔대적응용전경.
Brain-derived neurotrophic factor is the ligands of tyrosine kinase receptor B,for the binding of brain-derived neurotrophic factor to tyrosine kinase receptor B receptor,signal transmitted to the nucleus,resulting in a variety of biological effects.Lots of researchs had found that brain-derived neurotrophic factor and tyrosine kinase receptor B expression in malignant tumors more than non-cancerous adjacent tissue and normal tissue,and their effect can promote tumor blood vessel formation,suppress of cell anoikis,promote tumor growth,differentiation and metastasis.The relationship of brain-derived neurotrophic factor and tyrosine kinase receptor B provide a new therapeutic strategy for clinical treatment.From the current basic and clinical research,this treatment strategy has great prospect.