CAJ | 학술논문

肥大细胞参与介导炎症和免疫反应.通过实验诱导构建肥大细胞缺陷的腹主动脉瘤动物模型发现,肥大细胞通过几个不同机制参与腹主动脉瘤的发生.肥大细胞通过激活金属蛋白酶类和肾素-血管紧张素系统,导致平滑肌细胞凋亡,释放金属蛋白溶解酶类进而导致腹主动脉瘤的形成.同时,活化的肥大细胞也可以促进新生血管的重建、炎症反应、动脉粥样硬化,这些也是腹主动脉瘤形成的标志.因此,我们设想肥大细胞稳定剂同白三烯受体拮抗剂和组胺受体阻断剂一样,可能在腹主动脉瘤的治疗过程中有一定的功效和作用.
비대세포삼여개도염증화면역반응.통과실험유도구건비대세포결함적복주동맥류동물모형발현,비대세포통과궤개불동궤제삼여복주동맥류적발생.비대세포통과격활금속단백매류화신소-혈관긴장소계통,도치평활기세포조망,석방금속단백용해매류진이도치복주동맥류적형성.동시,활화적비대세포야가이촉진신생혈관적중건、염증반응、동맥죽양경화,저사야시복주동맥류형성적표지.인차,아문설상비대세포은정제동백삼희수체길항제화조알수체조단제일양,가능재복주동맥류적치료과정중유일정적공효화작용.
Mast cells regulate inflammation and immunity.Experimentally induced abdominal aortic aneurysm in mast cells-deficient animals and animals treated with mast cells inhibitors demonstrate that mast cells are involved in the pathogenesis of abdominal aortic aneurysm via several different mechanisms.Mast cells-dependent activation of metalloproteinases and the renin-angiotensin system,contribution to smooth muscle cell apoptosis,and release of proteolytic enzymes are some key examples.Activated mast cells also contribute to neovascularization,inflammation,and atherosclerosis,all hallmarks of abdominal aortic aneurysm.Thus,we may envision that mast cells stabilizing agents,as well as leukotriene receptor antagonists and histamine receptor blockers already in clinical use for treatment of other diseases,could also be tested for their efficacy in treatment of abdominal aortic aneurysm.