CAJ | 학술논문

脓毒症是一种常见的急性全身性感染,严重脓毒症的病死率极高,且发病率逐年上升.由于脓毒症状态下自由基过量产生,导致微循环血流障碍,进而多脏器功能受损.本文复习了抗坏血酸在脓毒症中的作用,它能通过内皮型一氧化氮合酶依赖的机制迅速扭转脓毒症造成的氧化应激损伤,发挥抗血小板黏附效应,抑制毛细血管栓塞,恢复微循环血流,从而改善患者的生存情况.
농독증시일충상견적급성전신성감염,엄중농독증적병사솔겁고,차발병솔축년상승.유우농독증상태하자유기과양산생,도치미순배혈류장애,진이다장기공능수손.본문복습료항배혈산재농독증중적작용,타능통과내피형일양화담합매의뢰적궤제신속뉴전농독증조성적양화응격손상,발휘항혈소판점부효응,억제모세혈관전새,회복미순배혈류,종이개선환자적생존정황.
Sepsis is a common acute systemic infection,severe sepsis has a high rate of mortality,and its incidence rate is rising year by year.Due to the overproduction of free radicals in sepsis,microcirculation blood is drived disorder,multiple organ function can be impaired.This review describes the role of ascorbic acid in sepsis patients,which can reverse the oxidative stress injury rapidly through an eNOS-dependent mechanism,resisting platelet adhersion,preventing capillary embolism,resevering microcirculation blood flow,so as to improve patients' survival.