国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2013年
6期
405-408
,共4页
髓源性抑制细胞%T淋巴细胞%树突细胞%自然杀伤细胞%自然杀伤T细胞%巨噬细胞%调节性T细胞
髓源性抑製細胞%T淋巴細胞%樹突細胞%自然殺傷細胞%自然殺傷T細胞%巨噬細胞%調節性T細胞
수원성억제세포%T림파세포%수돌세포%자연살상세포%자연살상T세포%거서세포%조절성T세포
Myeloid-derived suppressor cells%T-lymphocytes%Dendritic cell%Nature killer cell%Natural killer T cell%Macrophage%Regulate T cell
髓源性抑制细胞是一群异质性细胞的统称,包括各种分化状态的骨髓祖细胞、未成熟粒细胞、巨噬细胞和树突细胞等.髓源性抑制细胞可以抑制肿瘤毒性自然杀伤细胞和自然杀伤T细胞介导的固有免疫,以及CD4+CD8+T细胞介导的适应性免疫,并与巨噬细胞、树突细胞、调节性T细胞等有着密切联系,在肿瘤的发生、发展过程中起着重要的作用.
髓源性抑製細胞是一群異質性細胞的統稱,包括各種分化狀態的骨髓祖細胞、未成熟粒細胞、巨噬細胞和樹突細胞等.髓源性抑製細胞可以抑製腫瘤毒性自然殺傷細胞和自然殺傷T細胞介導的固有免疫,以及CD4+CD8+T細胞介導的適應性免疫,併與巨噬細胞、樹突細胞、調節性T細胞等有著密切聯繫,在腫瘤的髮生、髮展過程中起著重要的作用.
수원성억제세포시일군이질성세포적통칭,포괄각충분화상태적골수조세포、미성숙립세포、거서세포화수돌세포등.수원성억제세포가이억제종류독성자연살상세포화자연살상T세포개도적고유면역,이급CD4+CD8+T세포개도적괄응성면역,병여거서세포、수돌세포、조절성T세포등유착밀절련계,재종류적발생、발전과정중기착중요적작용.
Myeloid-derived suppressor cells are a heterogeneous population of early myeloid progenitors,immature granulocytes,macrophages,and dendritic cells at different stages of differentiation.These cells have the capacity to suppress both the innate immunity response mediated by the cytotoxic natural killer cells and natural killer T cells,and the adaptive immune response mediated by CD4+ and CD8+ T cells.In addition,myeloid-derived suppressor cells have close links with macrophages,dendritic cells,regulate T cells and so on,and also play an important role in the process of tumor progression.
