国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2013年
9期
611-614,封3
,共5页
乳腺肿瘤%基质金属蛋白酶13%总体生存率%预后
乳腺腫瘤%基質金屬蛋白酶13%總體生存率%預後
유선종류%기질금속단백매13%총체생존솔%예후
Breast neoplasms%Matrix metalloproteinase 13%Overall survival%Prognosis
目的 探讨基质金属蛋白酶-13(MMP-13)与乳腺癌临床病理特征的关系及其对乳腺癌总体生存率的影响.方法 选取包含生存资料的159点乳腺癌组织芯片MMP-13(126例病例),免疫组织化学方法测定组织芯片中MMP-13的表达.统计分析MMP-13在乳腺癌组织、癌组织与癌旁组织中的表达差异；MMP-13表达与乳腺癌肿瘤大小、组织学分级、TNM分期、淋巴结转移、ER表达、PR表达、HER2表达的相关性；高MMP-13表达组与低MMP-13表达组的乳腺癌总体生存率的差异.结果 MMP-13在乳腺癌组织(54.4％)中的表达明显高于癌旁组织(27.5％)(P=0.003);MMP-13表达与淋巴结转移(r=0.257,P=0.006)、临床TNM分期(r=0.310,P =0.001)、HER2表达(r=0.192,P=0.041)呈正相关,而与肿瘤大小(r=0.143,P=0.128)、肿瘤组织学分级(r=0.010,P=0.915)、ER/PR表达的相关性差异均无统计学意义.MMP-13高表达组乳腺癌病例总体生存率较低表达组明显降低.结论 MMP-13高表达是乳腺癌淋巴结转移的高危因素和独立的小良预后因素.
目的 探討基質金屬蛋白酶-13(MMP-13)與乳腺癌臨床病理特徵的關繫及其對乳腺癌總體生存率的影響.方法 選取包含生存資料的159點乳腺癌組織芯片MMP-13(126例病例),免疫組織化學方法測定組織芯片中MMP-13的錶達.統計分析MMP-13在乳腺癌組織、癌組織與癌徬組織中的錶達差異；MMP-13錶達與乳腺癌腫瘤大小、組織學分級、TNM分期、淋巴結轉移、ER錶達、PR錶達、HER2錶達的相關性；高MMP-13錶達組與低MMP-13錶達組的乳腺癌總體生存率的差異.結果 MMP-13在乳腺癌組織(54.4％)中的錶達明顯高于癌徬組織(27.5％)(P=0.003);MMP-13錶達與淋巴結轉移(r=0.257,P=0.006)、臨床TNM分期(r=0.310,P =0.001)、HER2錶達(r=0.192,P=0.041)呈正相關,而與腫瘤大小(r=0.143,P=0.128)、腫瘤組織學分級(r=0.010,P=0.915)、ER/PR錶達的相關性差異均無統計學意義.MMP-13高錶達組乳腺癌病例總體生存率較低錶達組明顯降低.結論 MMP-13高錶達是乳腺癌淋巴結轉移的高危因素和獨立的小良預後因素.
목적 탐토기질금속단백매-13(MMP-13)여유선암림상병리특정적관계급기대유선암총체생존솔적영향.방법 선취포함생존자료적159점유선암조직심편MMP-13(126례병례),면역조직화학방법측정조직심편중MMP-13적표체.통계분석MMP-13재유선암조직、암조직여암방조직중적표체차이；MMP-13표체여유선암종류대소、조직학분급、TNM분기、림파결전이、ER표체、PR표체、HER2표체적상관성；고MMP-13표체조여저MMP-13표체조적유선암총체생존솔적차이.결과 MMP-13재유선암조직(54.4％)중적표체명현고우암방조직(27.5％)(P=0.003);MMP-13표체여림파결전이(r=0.257,P=0.006)、림상TNM분기(r=0.310,P =0.001)、HER2표체(r=0.192,P=0.041)정정상관,이여종류대소(r=0.143,P=0.128)、종류조직학분급(r=0.010,P=0.915)、ER/PR표체적상관성차이균무통계학의의.MMP-13고표체조유선암병례총체생존솔교저표체조명현강저.결론 MMP-13고표체시유선암림파결전이적고위인소화독립적소량예후인소.
Objective To find out the correlation between MMP-13 and clinicopathological parameters of breast cancer and identify clinical significance of MMP-13 overexpression on overall survival of breast cancer.Methods Immunohistochemistry was performed on paraffin-embedded tissue microarray containing 159 tissue dots from breast cancer patients.The intensity and the extent of IHC were scored by pathologists blind to clinicopathological parameters of the specimens.Different expression profiles of MMP-13 in breat cancer tissues and paraneoplastic tissues,and correlation between MMP-13 and breast cancer clinicopathological parameters were analyzed for statistical significance respectively.The impact of MMP-13 overexpression on overall survival of breast cancer.Results MMP13 expression were significantly higher in breast cancer tissues(54.4％) than in their corresponding paraneoplastic tissues(27.5％)(P =0.003).Expression of MMP-13 in breast cancer positively correlated with lymphma node metastasis(r =0.257,P =0.006),clinical TNM classification (r =0.310,P =0.001),HER2 expression (r =0.192,P =0.041).However,no significant correlation were oberserved between MMP-13 expression and tumor size,MMP-13 expression and tumor grade,MMP-13 expression and ER expression,MMP-13 expression and PR expression respectively.Conclusions Overexpress of MMP-13 is more common in breast cancer tissues than in their corresponding paraneoplastic tissues,and is an independent prognosis indicator of breast cancer.
