CAJ | 학술논문

肝细胞癌是原发性肝癌的主要类型,也是常见的恶性肿瘤之一,具有较高的发病率和病死率.然而在分子和细胞水平,肝癌的发病机制仍然不清楚.一般来说,肿瘤形成通常被认为是抑癌基因失活或原癌基因激活致DNA突变而诱导人类正常细胞向恶性细胞转化的过程.近年来随着对肿瘤研究的不断深入,人们发现表观遗传学改变与肝癌发生发展密切相关.其中DNA甲基化是人类基因组发生最为常见的一种表观遗传学事件,也是表观遗传学研究最为深入的一种机制.本文将就DNA甲基化在肝癌中的研究进展作一综述.
간세포암시원발성간암적주요류형,야시상견적악성종류지일,구유교고적발병솔화병사솔.연이재분자화세포수평,간암적발병궤제잉연불청초.일반래설,종류형성통상피인위시억암기인실활혹원암기인격활치DNA돌변이유도인류정상세포향악성세포전화적과정.근년래수착대종류연구적불단심입,인문발현표관유전학개변여간암발생발전밀절상관.기중DNA갑기화시인류기인조발생최위상견적일충표관유전학사건,야시표관유전학연구최위심입적일충궤제.본문장취DNA갑기화재간암중적연구진전작일종술.
Hepatocellular carcinoma is one of the most common cancer with a high incidence and mortality,representing a main type of primary liver cancer.However,the molecular and cellular mechanisms of hepatocellular carcinoma pathogenesis are still poorly understood.Traditionally,the development of hepatocellular carcinoma has been viewed as a process of transforming of normal cells into malignant driven by the genetic alterations in tumor-suppressor gene deactivation and pro-oncogene activation.In recent years,with the deeper understanding of tumor,it has been found that epigenetic alterations are closely related to the occurrence and the development of hepatocellular carcinoma.DNA methylation is one of the most common epigenetic events occurring in human genome,as well as the best studied of the epigenetic changes.This review focuses on the state-of-the-art advancements of DNA methylation in hepatocellular carcinoma.