CAJ | 학술논문

瞬时受体电位(TRP)通道影响一些炎症反应和肿瘤的发生、发展.TRP通道分布广泛,调节机制各异,通过感受细胞内外环境的各种刺激,参与痛觉、机械感觉、味觉的发生和维持细胞内外环境的离子稳态等众多生命活动,具有调节肌肉收缩、递质释放、细胞增生、细胞分化、基因转录、细胞凋亡及细胞死亡等作用.TRP通道亚型TRPM8是一种非选择性阳离子通道,最初作为一种前列腺特异性蛋白被克隆出来,现发现在结肠癌、肺癌、乳腺癌、胰腺癌以及皮肤来源的恶性肿瘤中均有表达.这篇综述旨在概述TRPM8在不同类型肿瘤中的表达和功能.
순시수체전위(TRP)통도영향일사염증반응화종류적발생、발전.TRP통도분포엄범,조절궤제각이,통과감수세포내외배경적각충자격,삼여통각、궤계감각、미각적발생화유지세포내외배경적리자은태등음다생명활동,구유조절기육수축、체질석방、세포증생、세포분화、기인전록、세포조망급세포사망등작용.TRP통도아형TRPM8시일충비선택성양리자통도,최초작위일충전렬선특이성단백피극륭출래,현발현재결장암、폐암、유선암、이선암이급피부래원적악성종류중균유표체.저편종술지재개술TRPM8재불동류형종류중적표체화공능.
Transient receptor potential (TRP) channels affect several inflammatory and neoplastic conditions.and are widely distributed and activated by multiple stimuli.Mean while,as the sensor to the changes in cellular local environments,TRP channels have multiple functions,including thermal,mechanical and taste sensing,as well as ion homeostasis maintaining.They can regulate muscle contractions,transmitter release,cell multiplication,cell differentiation,genetic transcription,apoptosis and molecular death.TRPM8,a nonselective cation channel,was originally cloned as a prostate-specific protein.Now,TRPM8 is found in carcinoma of colon,lung cancer,mammary cancer,pancreatic cancer and cutaneum carcinoma.The aim of this review is to summarize data reported so far on the expression and functional role of TRPM8 channels in different types of cancers.