CAJ | 학술논문

肿瘤微环境是指肿瘤细胞在生长过程中,由肿瘤细胞及细胞外间质相互作用后形成的肿瘤细胞生长的特殊环境.肿瘤微环境作为保护和支持肿瘤发生、发展及转移复发的必要机构功能单元的理论已为越来越多的学者所接受.而最新的研究证据表明,exosomes在肿瘤微环境中,参与了细胞与细胞间的沟通,对肿瘤的进展可能起到了举足轻重的作用.本文总结近年来的文献,就exosomes的性质、生物学作用以及作为肿瘤微环境的重要组成部分在肿瘤进展中的潜在作用作一综述.
종류미배경시지종류세포재생장과정중,유종류세포급세포외간질상호작용후형성적종류세포생장적특수배경.종류미배경작위보호화지지종류발생、발전급전이복발적필요궤구공능단원적이론이위월래월다적학자소접수.이최신적연구증거표명,exosomes재종류미배경중,삼여료세포여세포간적구통,대종류적진전가능기도료거족경중적작용.본문총결근년래적문헌,취exosomes적성질、생물학작용이급작위종류미배경적중요조성부분재종류진전중적잠재작용작일종술.
The tumor microenvironment is a special environment including tumor cells,stromal cells and extracellular matrix.The notion that the tumor microenvironment is a necessary functional unit to support cancer progression,metastasis and recurrence has been accepted by more and more scholars.Studies have shown that exosomes may play a pivotal role in tumor progression that involved in cell-cell communication in the tumor microenvironment.Here,we summarize the recent publications on the characteristics of exosomes,its biological effects and the potential roles as an important part of the tumor microenvironment during tumor progression.