CAJ | 학술논문

胰腺癌是一种恶性程度很高的消化道肿瘤,近年来胰腺癌发病率有明显升高的趋势.由于胰腺癌早期确诊率不高,其手术切除率很低,预后极差.因此,提高胰腺癌的早期诊断率对于改善本病的预后有着很重要的意义.胰腺癌的早期诊断在很大程度上依赖肿瘤标志物的检测,近年来蛋白质组学技术发展迅速,广泛应用于临床研究,为肿瘤标志物的寻找提供了一条有效的途径.在所有的标本中,血清因其容易取得,允许重复检测等特点,成为最理想的生物学标本.本文就蛋白质组学技术在胰腺癌患者血清检测中的作用进行综述.
이선암시일충악성정도흔고적소화도종류,근년래이선암발병솔유명현승고적추세.유우이선암조기학진솔불고,기수술절제솔흔저,예후겁차.인차,제고이선암적조기진단솔대우개선본병적예후유착흔중요적의의.이선암적조기진단재흔대정도상의뢰종류표지물적검측,근년래단백질조학기술발전신속,엄범응용우림상연구,위종류표지물적심조제공료일조유효적도경.재소유적표본중,혈청인기용역취득,윤허중복검측등특점,성위최이상적생물학표본.본문취단백질조학기술재이선암환자혈청검측중적작용진행종술.
Pancreatic cancer is a kind of high degree of malignant gastrointestinal tumor,and its incidence has increased significantly in recent years.Due to the low early diagnosis rate,and the extreme low middile or late resection rate of pancreatic cancer,Pancreatic cancer's prognosis is poor.Therefore,improving the early diagnostic rate of pancreatic cancer has very important significance for improving the prognosis.Early diagnosis of pancreatic cancer is dependent on tumor markers detection to a great extent.And proteomics progress rapidly in recent years and has been widely applied in clinical research.It provides an effective way to find markers.Among all of the spec imens,secrum is easy to obtain,and it allows repetitive detection.What is more,secmm is also renewable.So it is the most ideal for biological specimens.In this review,the proteomics technology role in pancreatic cancer patients serum detection were summarized.