CAJ | 학술논문

丙型肝炎病毒(hepatitis C virus,HCV)是一种主要经过血液传播的肝炎病毒,是造成慢性肝炎、肝硬化甚至肝癌的主要原因之一.急性感染者,大约30％发生自发清除.已进展为慢性丙型肝炎(chronic hepatitis C,CHC)的患者,经抗病毒治疗,大约40％得到持久的HCV清除.目前,聚乙二醇干扰素-α(pegylated interferon-α,PEG-IFN-α)和利巴韦林(riba-virin,RBV)联合治疗是慢性丙型肝炎的标准治疗方案.近年的研究发现,不同基因型病毒感染的患者对治疗的敏感性有所不同,而不同种族和不同个体对干扰素治疗的应答也有很大差异,即影响慢性丙型肝炎患者抗病毒治疗疗效的因素主要是病毒和宿主两方面.此文就不同的人群基因背景和感染的HCV不同亚型两个方面对慢性丙型肝炎患者治疗效果的影响作一综述.
병형간염병독(hepatitis C virus,HCV)시일충주요경과혈액전파적간염병독,시조성만성간염、간경화심지간암적주요원인지일.급성감염자,대약30％발생자발청제.이진전위만성병형간염(chronic hepatitis C,CHC)적환자,경항병독치료,대약40％득도지구적HCV청제.목전,취을이순간우소-α(pegylated interferon-α,PEG-IFN-α)화리파위림(riba-virin,RBV)연합치료시만성병형간염적표준치료방안.근년적연구발현,불동기인형병독감염적환자대치료적민감성유소불동,이불동충족화불동개체대간우소치료적응답야유흔대차이,즉영향만성병형간염환자항병독치료료효적인소주요시병독화숙주량방면.차문취불동적인군기인배경화감염적HCV불동아형량개방면대만성병형간염환자치료효과적영향작일종술.
Hepatitis C virus (HCV) is one of hepatitis viruses,transmits mainly through blood and one of the major reasons to cause chronic hepatitis,liver cirrhosis and liver cancer.HCV infection is spontaneously resolved in about 30％ of acutely infected individuals.In those who develop chronic hepatitis,HCV therapy permanently eradicates infection in about 40 ％ of case after using antiviral therapy.At present,a combined therapy of pegylated interferon-α (PEG-IFN-α) and ribavirin (RBV) is recommended as standard of care for patients with chronic HCV infection.Recent studies have suggested that not only the patients who had been infected with different virus genotypes show different sensitivity to treatment,but also the patients from different ethnic backgrounds and even different individuals show quite difference in response to interferon therapy.Therefore,it is believed that both the viral and host' s genetic backgrounds would affect the antiviral therapy.This review describes the factors of both genetic background of human populations and different HCV genotypes that affect the outcome of anti-HCV treatment.