CAJ | 학술논문

随着尿毒症患者数量的增加,尿毒症患者合并恶性肿瘤的发生率呈上升趋势,影响着尿毒症患者的生命安全和进一步行肾移植治疗的效果..此文通过阅读近几年来国内外最新相关文献,总结尿毒症患者与肿瘤发生相关的一些基因表达情况,发现尿毒症患者的DNA修复功能受损；原癌基因ras、c-myc基因表达上调；抑癌基因p-53表达下调,Klotho基因表达下调,其中Klotho基因被认为是一种新型抑癌基因,认为这些基因表达的异常可能与尿毒症患者肿瘤发生率较高有关.尿毒症患者容易发生肿瘤的风险早期可以在基因表达水平上表现异常,认识这些指标可以早期监测尿毒症患者发生肿瘤风险性大小的情况,以便对肾移植受体的选择起到一定的筛查作用,避免肿瘤高风险的患者进行肾移植术治疗.
수착뇨독증환자수량적증가,뇨독증환자합병악성종류적발생솔정상승추세,영향착뇨독증환자적생명안전화진일보행신이식치료적효과..차문통과열독근궤년래국내외최신상관문헌,총결뇨독증환자여종류발생상관적일사기인표체정황,발현뇨독증환자적DNA수복공능수손；원암기인ras、c-myc기인표체상조；억암기인p-53표체하조,Klotho기인표체하조,기중Klotho기인피인위시일충신형억암기인,인위저사기인표체적이상가능여뇨독증환자종류발생솔교고유관.뇨독증환자용역발생종류적풍험조기가이재기인표체수평상표현이상,인식저사지표가이조기감측뇨독증환자발생종류풍험성대소적정황,이편대신이식수체적선택기도일정적사사작용,피면종류고풍험적환자진행신이식술치료.
With increasing numbers of uremic patients being diagnosed,the number of patients diagnosed with both uremia and malignant tumors is also rising.This will have influences on the patients'mortality,and the therapeutic outcome of kidney transplantation.This review is to explore/summarize the carcinogenic factors within uremic patients,and to analyse the expression of the tumor-related genes in uremic patients via reading related literatures published in homeland and abroad,recent years.Among the uremic patients,regardless of dialysis treatment,we found that the function of the DNA repair is damaged,expression of the proto-oncogene ras and c-myc are up-regulated,and the anti-oncogene p-53 and the Klotho genes are down-regulated.Abnormal expression of these genes may be contributing to the high incidence of cancers within uremic patients.Understanding of these abnormal gene regulations may further help to estimate the risk for malignant tumors among uremic patients in the early stage,and to screen the appropriate kidney transplant recipients.On the other hand,a uremic patient at high-risk for cancer may not be a candidate for kidney transplantation.