国际遗传学杂志
國際遺傳學雜誌
국제유전학잡지
INTERNATIONAL JOURNAL OF GENETICS
2013年
1期
42-45
,共4页
王迪%王霄龙%韩福洲%吕洪光
王迪%王霄龍%韓福洲%呂洪光
왕적%왕소룡%한복주%려홍광
信号转导和转录活化因子3(STAT3)%胃癌%增殖%侵袭%转移
信號轉導和轉錄活化因子3(STAT3)%胃癌%增殖%侵襲%轉移
신호전도화전록활화인자3(STAT3)%위암%증식%침습%전이
Signal transducer and activator of transcription 3 (STAT3)%Gastric cancers%Proliferation%Invasion%Migration
胃癌在全球癌症致死性疾病中位列第3位.近几年的研究发现,信号转导和转录活化因子3 (signal transducer and activator of transcription 3,STAT3)在胃癌中呈过度激活状态.STAT3的异常激活可促进胃癌细胞的增殖、侵袭和转移,并抑制胃癌细胞的凋亡.相关实验证实,抑制STAT3的表达和阻断上游细胞因子的信号转导可降低胃癌的致瘤性.因此,针对STAT3的研究将为胃癌的临床治疗提供新靶点.此文综述了STAT3的结构特点以及其与胃癌发生发展关系的研究进展.
胃癌在全毬癌癥緻死性疾病中位列第3位.近幾年的研究髮現,信號轉導和轉錄活化因子3 (signal transducer and activator of transcription 3,STAT3)在胃癌中呈過度激活狀態.STAT3的異常激活可促進胃癌細胞的增殖、侵襲和轉移,併抑製胃癌細胞的凋亡.相關實驗證實,抑製STAT3的錶達和阻斷上遊細胞因子的信號轉導可降低胃癌的緻瘤性.因此,針對STAT3的研究將為胃癌的臨床治療提供新靶點.此文綜述瞭STAT3的結構特點以及其與胃癌髮生髮展關繫的研究進展.
위암재전구암증치사성질병중위렬제3위.근궤년적연구발현,신호전도화전록활화인자3 (signal transducer and activator of transcription 3,STAT3)재위암중정과도격활상태.STAT3적이상격활가촉진위암세포적증식、침습화전이,병억제위암세포적조망.상관실험증실,억제STAT3적표체화조단상유세포인자적신호전도가강저위암적치류성.인차,침대STAT3적연구장위위암적림상치료제공신파점.차문종술료STAT3적결구특점이급기여위암발생발전관계적연구진전.
Gastric cancer is the third most common cause of cancer-related mortality worldwide.In recent years,it has been found that signal transducer and activator of transcription 3 (STAT3) are commonly overexpressed in gastric cancer calls.Abnormal activation of STAT3 promotes proliferation,invasion and metastasis of gastric cancer cells,and inhibits apoptosis of gastric cancer calls.Blocking the signal transduction of STAT3 may prevent or inhibit the development of gastric cancers.Many studies have confirmed that either inhibition of STAT3 expression or blocking of upstream cytokines may be therapeutically effective in preventing gastric carcinogenesis.Therefore,STAT3 is a novel target for the treatment of gastric cancers.
