CAJ | 학술논문

一碳单位代谢的主成分叶酸作为DNA合成、损伤修复及甲基化等生物过程的重要微营养素.许多证据都表明叶酸与结直肠癌(cdorectal cancer,CRC)发病风险具有一定关系.亚甲基四氢叶酸还原酶(methylenetotrahydrofolate reductase,MTHFR)、甲硫氨酸合成酶(methionine synthase,MTR)和甲硫氨酸合成酶还原酶(methione synthase reductase,MTRR)是叶酸代谢中的关键酶,其酶活性变化可能通过不同方式影响叶酸代谢过程从而参与到结直肠癌的发生发展过程中.该文结合近年来的一些研究重点综述了上述叶酸代谢关键酶基因的多态性,及其所导致的酶功能变异与CRC风险的关系.
일탄단위대사적주성분협산작위DNA합성、손상수복급갑기화등생물과정적중요미영양소.허다증거도표명협산여결직장암(cdorectal cancer,CRC)발병풍험구유일정관계.아갑기사경협산환원매(methylenetotrahydrofolate reductase,MTHFR)、갑류안산합성매(methionine synthase,MTR)화갑류안산합성매환원매(methione synthase reductase,MTRR)시협산대사중적관건매,기매활성변화가능통과불동방식영향협산대사과정종이삼여도결직장암적발생발전과정중.해문결합근년래적일사연구중점종술료상술협산대사관건매기인적다태성,급기소도치적매공능변이여CRC풍험적관계.
Folate is a indispensable micronutrient,and as a critical component in one-carbon metabolism,folate is engaged in DNA synthesis,repair and methylation.Lots of evidence supports the important roles of folate in the etiology of colorectal cancer (CRC) Methylenetetrahydrofolate reductase (MTHFR),methionine synthase (MTR) and methione synthase reductase (MTRR) are three key enzymes played essential roles in folate metabolism.The activities changed in these metabolic enzymes might influence folate metabolism and take part in colorectal carcinogenesis.This review summaried some advanced researches,particularly in the gene polymorphism involved in these metabolic enzymes and the relationship of the resulted functional variations with the risks of CRC.