国际生物制品学杂志
國際生物製品學雜誌
국제생물제품학잡지
INTERNATIONAL JOURNAL OF BIOLOGICALS
2013年
1期
26-29
,共4页
双特异性抗体%IgG%靶向治疗
雙特異性抗體%IgG%靶嚮治療
쌍특이성항체%IgG%파향치료
Bispecific antibody%IgG%Targeted therapy
双特异性IgG在抑制肿瘤时预期具有很好的应用前景.早期,杂交瘤细胞融合或共转染表达两个抗体产生的双特异性IgG产量低且难以纯化.现在已经有多种构建双特异性IgG的方法.此文介绍几种双特异性IgG最新构建策略.
雙特異性IgG在抑製腫瘤時預期具有很好的應用前景.早期,雜交瘤細胞融閤或共轉染錶達兩箇抗體產生的雙特異性IgG產量低且難以純化.現在已經有多種構建雙特異性IgG的方法.此文介紹幾種雙特異性IgG最新構建策略.
쌍특이성IgG재억제종류시예기구유흔호적응용전경.조기,잡교류세포융합혹공전염표체량개항체산생적쌍특이성IgG산량저차난이순화.현재이경유다충구건쌍특이성IgG적방법.차문개소궤충쌍특이성IgG최신구건책략.
There are promising prospects for IgG-format bispecific antibodies in applications of cancer therapy.In early experiments,bispecific IgG created by quadromas or coexpression of two IgG had poor production yields and could not be purified easily.Recently,there are many technologies for constructing bispecific IgG.This review describes the latest progress in various approaches to the engineering of bispecific IgG.
