CAJ | 학술논문

作为一类广泛参与细胞能量代谢、周期控制和免疫应答等生命过程的重要蛋白,去乙酰化酶Sirt1还具有明显的神经元保护作用.同时,Sirt1在许多视网膜疾病动物模型的干预中展示了不可忽视的作用.本文对这一领域的研究进展进行了综述,主要包括:在糖尿病视网膜病变中,Sirt1能够抑制视网膜的慢性炎症反应、减少视网膜新生血管生成并清除视网膜细胞的高血糖记忆;在视神经炎和青光眼模型中,Sirt1能保护视网膜神经节细胞,减少其凋亡;而在年龄相关性黄斑变性模型中,Sirt1能保护视网膜色素上皮细胞的活力和功能,并降低补体因子引起的视网膜自身免疫反应.在脉络膜新生血管生成过程中,Sirt1可能具有促血管增生作用,但尚需进一步研究.由于Sirt1活性对于减轻多种视网膜疾病的组织损伤均具有重要作用,因此Sirt1是治疗视网膜病变很有前景的靶点.
작위일류엄범삼여세포능량대사、주기공제화면역응답등생명과정적중요단백,거을선화매Sirt1환구유명현적신경원보호작용.동시,Sirt1재허다시망막질병동물모형적간예중전시료불가홀시적작용.본문대저일영역적연구진전진행료종술,주요포괄:재당뇨병시망막병변중,Sirt1능구억제시망막적만성염증반응、감소시망막신생혈관생성병청제시망막세포적고혈당기억;재시신경염화청광안모형중,Sirt1능보호시망막신경절세포,감소기조망;이재년령상관성황반변성모형중,Sirt1능보호시망막색소상피세포적활력화공능,병강저보체인자인기적시망막자신면역반응.재맥락막신생혈관생성과정중,Sirt1가능구유촉혈관증생작용,단상수진일보연구.유우Sirt1활성대우감경다충시망막질병적조직손상균구유중요작용,인차Sirt1시치료시망막병변흔유전경적파점.
Besides involved in metabolism process,cell cycle control and immune response,Sirtuinl (Sirt1),a member of Class Ⅲ Histone deacetylase (HDAC),also demonstrated neuroprotective effects on the retinal cells in several retinal and optic nerve diseases.The roles of Sirtl in the development of retina diseases were reviewed and summarized in this article.The main points included:in diabetic retinopathy models,Sirtl could inhibit the retinal chronic inflammation,attenuate the retinal neovascularization and cleavage the metabolic memory of retina cells ; in optic neuritis and glaucoma models,Sirtl protected retinal ganglion cells (RGCs) from apoptosis; in age-related macular degeneration (AMD) study,Sirt1 had been proved to be able to rescue the viability and function of retinal pigment epithelium (RPE) cells in vitro,and decrease the complement factor (CF) H-induced retinal autoimmunity.On the other hand,Sirt1,as a possible angiogenesis factor,may promote choroidal neovascularization,which needs further confirmation.Sirt1 might be a potential therapeutic target in retinal diseases.