CAJ | 학술논문

手术后瘢痕化是导致青光眼滤过手术失败的主要原因.多种细胞因子,如转化生长因子β(TGF-β)、血管内皮生长因子(VEGF)、结缔组织生长因子(CTGF)、白细胞介素(IL-1)和干扰素(INF)等参与青光眼滤过手术瘢痕化过程的调控.目前已研制出多种针对这些细胞因子的治疗性干预措施,在预防青光眼手术滤过通道瘢痕化方面具有很好的应用前景.本文对参与调控青光眼滤过手术瘢痕化的细胞因子以及针对性治疗措施进行综述.
수술후반흔화시도치청광안려과수술실패적주요원인.다충세포인자,여전화생장인자β(TGF-β)、혈관내피생장인자(VEGF)、결체조직생장인자(CTGF)、백세포개소(IL-1)화간우소(INF)등삼여청광안려과수술반흔화과정적조공.목전이연제출다충침대저사세포인자적치료성간예조시,재예방청광안수술려과통도반흔화방면구유흔호적응용전경.본문대삼여조공청광안려과수술반흔화적세포인자이급침대성치료조시진행종술.
Following all types of glaucoma filtration surgery,scarring still poses the major threat to long-term success.Many cytokines,such as transforming growth factor-β (TGF-β),vascular endothelial growth factor (VEGF),connective tissue growth factor (CTGF),interleukin (IL) and interferon (INF),are associated with the scarring progress after filtration surgery.Recently,many promising new agents were used therapeutically by binding to these molecular targets among scar regulation after glaucoma surgery.In this review,we discuss our current understanding of cytokines in the wound healing process after glaucoma surgery and promising new treatment modalities.